Research Article

A Systems’ Biology Approach to Study MicroRNA-Mediated Gene Regulatory Networks

Figure 3

Different p21 dynamics in different network motifs. We ran simulations to show the different dynamics of p21 for two different network motifs (a) and (b). Through simulations, two dynamical patterns of p21 were identified: saturation and pulse ((c), top). For each network motif, the corresponding distributions of the two dynamical patterns were plotted ((c), bottom). For different combinations of the transcriptional strengths, the normalized distance ( ) between peaks ( ) and steady states ( ) of p21 is determined by the equation . If , for the corresponding combination of transcriptional strengths the p21 dynamics is saturation, otherwise it is pulse. The regions showing different dynamical patterns of p21 are separated using the white lines.
703849.fig.003a
(a)
703849.fig.003b
(b)
703849.fig.003c
(c)