Enhanced Production of Acarbose and Concurrently Reduced Formation of Impurity C by Addition of Validamine in Fermentation of Actinoplanes utahensis ZJB-08196
Figure 2
Effect of exogenous addition of C7N-aminocyclitols on the acarbose fermentation in batch culture by A. utahensis ZJB-08196. Symbols: black bar: impurity C; lined bar: acarbose. Fermentations were carried out at 28°C and 200 rpm for 168 h in fermentation medium with the addition of different C7N-aminocyclitols at a final concentration of 80 mg/L prior to the inoculation. The error bars in the figure indicate the standard deviations from three independent samples. *indicates statistic significance () compared to control experiments without the addition of C7N-aminocyclitols.
