Clinical Study

Distal Airway Impairment in Obese Normoreactive Women

Table 1

Lung function data of the BMI-normal, overweight, and obese patients, in the entire population.

VariablesTotalBMI < 2525 ≤ BMI < 30BMI ≥ 30 value

Smoking0.2350
 Yes39 (13.31)29 (15.93)8 (12.90)2 (4.08)
 No228 (77.82)137 (75.27)50 (80.65)41 (83.67)
 Former smoker26 (8.87)16 (8.76)4 (6.45)6 (12.24)
Age (years)41.04 (12.80)37.91 (12.76)45.38 (12.39)***47.18 (9.32)**<0.0001
BMI (kg/m2)24.65 (5.41)21.22 (2.19)27.45 (1.51)***33.83 (4.02)***<0.0001
FVC (L)3.20 (0.59)3.36 (0.54)2.99 (0.61)**2.89 (0.56)***<0.0001
FVC (% pred)0.99 (0.14)1.01 (0.14)0.97 (0.13)0.98 (0.15)0.1094
FEV1 (L)2.72 (0.54)2.88 (0.52)2.49 (0.49)**2.42 (0.48)**<0.0001
FEV1 (% pred)0.98 (0.14)0.99 (0.14)0.94 (0.13)*0.97 (0.16)0.0287
FEV1/FVC (%)0.85 (0.06)0.86 (0.07)0.84 (0.05)*0.84 (0.05)*0.0375
FVC fall (%)11.32 (8.71)10.66 (8.84)10.85 (8.07)14.37 (8.53)**0.0111
FEV1 fall (%)16.92 (9.96)16.72 (10.38)15.17 (9.40)19.86 (8.53)*0.0230
FVC DRS0.03 (0.10)0.03 (0.11)0.02 (0.03)0.05 (0.11)**0.0008
FEV1 DRS0.04 (0.13)0.04 (0.15)0.03 (0.05)0.07 (0.15)**0.0008
CI0.68 (0.57)0.67 (0.64)0.72 (0.53)0.71 (0.28)0.1142

Data are presented as median (interquartile range) (all but smoking) and (%) (smoking). BMI: body mass index; FEV1: forced expiratory volume in one second; FVC: forced volume capacity; DRS: dose-response slope; CI: closing index.
* versus BMI < 25; ** versus BMI < 25; *** versus BMI < 25.