Immunocytochemical Characterization of Alzheimer Disease Hallmarks in APP/PS1 Transgenic Mice Treated with a New Anti-Amyloid-β Vaccine
Figure 3
Different types of β-amyloid plaques in APP/PS1 mouse brains. (a)–(d): Different types of β-amyloid plaques observed in APP/PS1 mice based on the morphological classification: type 1 plaque (a), devoid of a central dense core and displaying an irregular shape; type 2a plaques (b) show a compact shape and exhibit a central core surrounded by fibrillar material; Plaque 2b (c), characterized by fibrillar material radiating from the central dense core; type 2c plaques (d) show a strong β-amyloid positivity without any surrounding fibrillar material.
