Temperature and Drug Treatments in Mevalonate Kinase Deficiency: An Ex Vivo Study

Figure 2

Columns of supernatant level (pg/mL) of IL-1ra, IL-2, IL-4, IL-6, IL-9, IL-12(p70), IL-15, IL-17, Eotaxin, FGF-basic, IFN-γ, IP-10, MIP-1α, PDGF-BB, and VEGF both at 37°C and at 40°C, in untreated condition and after administration of LPS alone or in combination with GOH or Typ. *𝑃<0.05; **𝑃<0.01; ***𝑃<0.001; one-way ANOVA test followed by Bonferroni’s multiple comparison test. LPS: lipopolysaccharide; GOH: geraniol; Typ: Tipifarnib.

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