Temperature and Drug Treatments in Mevalonate Kinase Deficiency: An Ex Vivo Study
Table 2
Levels of cytokines tested in the untreated and LPS-stimulated MKD patients’ monocytes, both at 37°C and 40°C.
Cytokine
Patients’ monocytes
37°C
40°C
Untreated
LPS
Untreated
LPS
IL-1β
IL-1ra
IL-2
IL-4
IL-5
<2
<2
<2
<2
IL-6
IL-7
<2
<2
<2
<2
IL-8
IL-9
IL-10
IL-12(p70)
IL-13
IL-15
IL-17
Eotaxin
FGF-basic
G-CSF
GM-CSF
IFN-γ
IP-10
MCP-1
MIP-1α
PDGF-BB
MIP-1β
RANTES
TNF-α
VEGF
IL-1α
IL-2Rα
IL-3
IL-12(p40)
IL-16
IL-18
CTACK
GRO-α
HGF
IFN-α2
LIF
MCP-3
M-CSF
MIF
MIG
β-NGF
<2
<2
<2
<2
SCF
<1
<1
SCGF-β
SDF-1α
TNF-β
TRAIL
Values are expressed as mean ± SEM, in pg/mL; *, **, and *** versus the untreated groups tested at the same temperature: one-way ANOVA test followed by Bonferroni’s multiple comparison test.