Formulation Development and Stability Studies of Norfloxacin Extended-Release Matrix Tablets

Table 5

Coefficients of determination (𝑟²) obtained from dissolution of norfloxacin uncoated formulations according to different mathematical models.

Formulation	Zero order	First order	Higuchi	Korsmeyer-Peppas
	𝑟^2	𝑟^2	𝑟^2	𝑟^2	𝑛
HPMC K100LV 20%	0.9794	0.9247	0.9685	0.9952	0.9623
HPMC K100LV 30%	0.9794	0.8538	0.9681	0.9985	0.9761
HPMC K4M 20%	0.9943	0.9916	0.9604	0.9963	0.7115
HPMC K4M 30%	0.9834	0.9954	0.9801	0.9986	0.6593
PEO N60K 20%	0.9976	0.9302	0.9372	0.9994	0.9485
PEO N60K 30%	0.9978	0.9513	0.9127	0.9990	1.0027
PEO 301 20%	0.9978	0.9591	0.9180	0.9978	0.8900
PEO 301 30%	0.9978	0.9795	0.9308	0.9971	0.8771