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BioMed Research International
Volume 2013 (2013), Article ID 719570, 4 pages
Low Circulating Protein C Levels Are Associated with Lower Leg Ulcers in Patients with Diabetes
1Department of Dermatology, The University of Sydney, St Leonards, NSW 2065, Australia
2Sutton Arthritis Research Laboratory, Institute of Bone and Joint Research, Kolling Institute of Medical Research, Royal North Shore Hospital, The University of Sydney, St Leonards, NSW 2065, Australia
3Department of Endocrinology, The University of Sydney, St Leonards, NSW 2065, Australia
4Department of Haematology, Kolling Institute of Medical Research, Royal North Shore Hospital, The University of Sydney, St Leonards, NSW 2065, Australia
5Raymond Purves Research Laboratories, Institute of Bone and Joint Research, Kolling Institute of Medical Research, Royal North Shore Hospital, The University of Sydney, St Leonards, NSW 2065, Australia
Received 3 August 2012; Accepted 5 December 2012
Academic Editor: Jorge Berlanga Acosta
Copyright © 2013 K. Whitmont et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- C. T. Esmon, “The anticoagulant and anti-inflammatory roles of the protein C anticoagulant pathway,” Journal of Autoimmunity, vol. 15, no. 2, pp. 113–116, 2000.
- L. O. Mosnier, B. V. Zlokovic, and J. H. Griffin, “The cytoprotective protein C pathway,” Blood, vol. 109, no. 8, pp. 3161–3172, 2007.
- M. Xue, N. Minhas, S. O. Chow et al., “Endogenous protein C is essential for the functional integrity of human endothelial cells,” Cellular and Molecular Life Sciences, vol. 67, no. 9, pp. 1537–1546, 2010.
- M. Xue, S. O. Chow, S. Dervish, Y. K. Chan, S. Julovi, and C. J. Jackson, “Activated protein C enhances human keratinocyte barrier integrity via sequential activation of epidermal growth factor receptor and tie2,” The Journal of Biological Chemistry, vol. 286, pp. 6742–6750, 2010.
- K. Fukudome, S. Kurosawa, D. J. Stearns-Kurosawa, X. He, A. R. Rezaie, and C. T. Esmon, “The endothelial cell protein C receptor. Cell surface expression and direct ligand binding by the soluble receptor,” The Journal of Biological Chemistry, vol. 271, no. 29, pp. 17491–17498, 1996.
- S. Kurosawa, D. J. Stearns-Kurosawa, N. Hidari, and C. T. Esmon, “Identification of functional endothelial protein C receptor in human plasma,” Journal of Clinical Investigation, vol. 100, no. 2, pp. 411–418, 1997.
- G. R. Bernard, J. L. Vincent, P. F. Laterre et al., “Efficacy and safety of recombinant human activated protein C for severe sepsis,” The New England Journal of Medicine, vol. 344, no. 10, pp. 699–709, 2001.
- K. Whitmont, I. Reid, S. Tritton et al., “Treatment of chronic leg ulcers with topical activated protein C,” Archives of Dermatology, vol. 144, no. 11, pp. 1479–1483, 2008.
- C. Jackson, K. Whitmont, S. Tritton, L. March, P. Sambrook, and M. Xue, “New therapeutic applications for the anticoagulant, activated protein C,” Expert Opinion on Biological Therapy, vol. 8, no. 8, pp. 1109–1122, 2008.
- B. V. Zlokovic, C. Zhang, D. Liu, J. Fernandez, J. H. Griffin, and M. Chopp, “Functional recovery after embolic stroke in rodents by activated protein C,” Annals of Neurology, vol. 58, no. 3, pp. 474–477, 2005.
- B. Isermann, I. A. Vinnikov, T. Madhusudhan et al., “Activated protein C protects against diabetic nephropathy by inhibiting endothelial and podocyte apoptosis,” Nature Medicine, vol. 13, no. 11, pp. 1349–1358, 2007.
- H. Yasui, E. C. Gabazza, S. Tamaki et al., “Intratracheal administration of activated protein C inhibits bleomycin-induced lung fibrosis in the mouse,” American Journal of Respiratory and Critical Care Medicine, vol. 163, no. 7, pp. 1660–1668, 2001.
- A. Kumral, D. C. Yesilirmak, K. Tugyan et al., “Activated protein C reduces intestinal injury in an experimental model of necrotizing enterocolitis,” Journal of Pediatric Surgery, vol. 45, no. 3, pp. 483–489, 2010.
- C. J. Jackson, M. Xue, P. Thompson et al., “Activated protein C prevents inflammation yet stimulates angiogenesis to promote cutaneous wound healing,” Wound Repair and Regeneration, vol. 13, no. 3, pp. 284–294, 2005.
- M. Xue, P. Thompson, I. Kelso, and C. Jackson, “Activated protein C stimulates proliferation, migration and wound closure, inhibits apoptosis and upregulates MMP-2 activity in cultured human keratinocytes,” Experimental Cell Research, vol. 299, no. 1, pp. 119–127, 2004.
- M. Xue, D. Campbell, P. N. Sambrook, K. Fukudome, and C. J. Jackson, “Endothelial protein C receptor and protease-activated receptor-1 mediate induction of a wound-healing phenotype in human keratinocytes by activated protein C,” Journal of Investigative Dermatology, vol. 125, no. 6, pp. 1279–1285, 2005.
- M. Xue, D. Campbell, and C. J. Jackson, “Protein C is an autocrine growth factor for human skin keratinocytes,” The Journal of Biological Chemistry, vol. 282, no. 18, pp. 13610–13616, 2007.
- Expert Committee on the Diagnosis and Classification of Diabetes Mellitus, “Report of the expert committee on the diagnosis and classification of diabetes mellitus,” Diabetes Care, vol. 26, supplement 1, pp. S5–S20, 2003.
- T. C. Vukovich and G. Schernthaner, “Decreased protein C levels in patients with insulin-dependent type I diabetes mellitus,” Diabetes, vol. 35, no. 5, pp. 617–619, 1986.
- Y. Yano, E. C. Gabazza, N. Kitagawa et al., “Tumor necrosis, factor-α is associated with increased protein C activation in nonobese type 2 diabetic patients,” Diabetes Care, vol. 27, no. 3, pp. 844–845, 2004.
- Y. Liu, D. Min, T. Bolton et al., “Increased matrix metalloproteinase-9 predicts poor wound healing in diabetic foot ulcers,” Diabetes Care, vol. 32, no. 1, pp. 117–119, 2009.
- C. T. Esmon, “Protein C pathway in sepsis,” Annals of Medicine, vol. 34, no. 7-8, pp. 598–605, 2002.