Review Article

Tyrosine Kinase Inhibitors Induced Thyroid Dysfunction: A Review of Its Incidence, Pathophysiology, Clinical Relevance, and Treatment

Table 3

Frequency of reported hypothyroidism and hyperthyroidism for different tyrosine kinase inhibitors used.

Tyrosine kinase inhibitorsFrequency of hypothyroidismFrequency of isolated hyperthyroidism

Sunitinib53–85% 10%
Sorafenib20–36% 2.6–5%
Imatinib90–100% (only in patients who underwent previous thyroidectomies)0%
Motesanib diphosphate22% 0%
Vandetanib89%0%
Axitinib83–92% (small number of patients in studies included)16%
Pazopanib10–29%0%
Tivozanib5%0%