Ubiquitin Ligase Cbl-b Is Involved in Icotinib (BPI-2009H)-Induced Apoptosis and G1 Phase Arrest of <i>EGFR</i> Mutation-Positive Non-Small-Cell Lung Cancer

<table>Icotinib regulated phosphorylation of EGFR, Akt, and ERK. Western blot analysis of EGFR, Akt, and ERK protein expression in HCC827 cells treated with 0.01–1 <i>μ</i>mol/L icotinib. <i>β</i>-Actin was used as the internal control.</table>

BioMed Research International

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Figure 5

Figure 5: Ubiquitin Ligase Cbl-b Is Involved in Icotinib (BPI-2009H)-Induced Apoptosis and G1 Phase Arrest of <i>EGFR</i> Mutation-Positive Non-Small-Cell Lung Cancer 

Figure 5 | Ubiquitin Ligase Cbl-b Is Involved in Icotinib (BPI-2009H)-Induced Apoptosis and G1 Phase Arrest of EGFR Mutation-Positive Non-Small-Cell Lung Cancer 