Table 1: Differentially expressed genes in PC-treated via untreated OA meniscal cells.

Biological
process
Gene
name
Gene IDDifferential
expression*
Description

Cell proliferationBLMNM_000057−7.41Bloom syndrome, RecQ helicase-like
NDPNM_000266−4.68Norrie disease (pseudoglioma)
HELLSAF155827−4.46Helicase, lymphoid specific
E2F7AI341146−4.12E2F transcription factor 7
CDC7NM_003503−4.11Cell division cycle 7 homolog (S. cerevisiae)
CDCA7AY029179−2.71Cell division cycle-associated 7
CDC25CNM_001790−2.36Cell division cycle 25 homolog C (S. pombe)
BRCA1AF005068−3.60Breast cancer 1, early onset
BRCA2X95152−3.30Breast cancer 2, early onset
PRKRAAA279462−3.34PKinase, interferon-indu double-stranded RNA-dependent activator
HHIPAK098525−3.28Hedgehog interacting protein
CHEK1AA224205−3.11CHK1 checkpoint homolog (S. pombe)
PTPRKAU145587−3.08Protein tyrosine phosphatase, receptor type, K
GINS1NM_021067−3.07GINS complex subunit 1 (Psf1 homolog)
TCF19BC002493−2.93Transcription factor 19
MKI67AU147044−2.92Antigen identified by monoclonal antibody Ki-67
PDS5BAK026889−2.88PDS5, regulator of cohesion maintenance, homolog B
UHRF1AK025578−2.77Ubiquitin-like with PHD and ring finger domains 1
AURKBAB011446−2.64Aurora kinase B
MKI67AU132185−2.64Antigen identified by monoclonal antibody Ki-67
FIGNL1NM_022116−2.62Fidgetin-like 1
KIF15NM_020242−2.60Kinesin family member 15
LRP6NM_002336−2.55Low-density lipoprotein receptor-related protein 6
ANXA1AU155094−2.47Annexin A1
DDX11U33833−2.47DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 11
FANCAAW083279−2.46Fanconi anemia, complementation group A
SPRY2NM_005842−2.43Sprouty homolog 2 (Drosophila)
RECQL4NM_004260−2.43RecQ protein-like 4
NTN1BF591483−2.42Netrin 1
ADRB2NM_000024−2.41Adrenergic, beta-2, receptor, surface
CUL4AAU155661−2.40Cullin 4A
DLC1NM_024767−2.39Deleted in liver cancer 1
STILNM_003035−2.39SCL/TAL1 interrupting locus
CHEK1NM_001274−2.37CHK1 checkpoint homolog (S. pombe)
TIMELESSNM_003920−2.37Timeless homolog (Drosophila)
SMAD4AL832789−2.23SMAD family member 4
SMAD1NM_015583−2.19SMAD family member 1
PCNANM_002592−2.18Proliferating cell nuclear antigen
PRKCDNM_006254−2.17Protein kinase C, delta
RBBP4AI972451−2.16Retinoblastoma binding protein 4
PTGS1NM_000962−2.13Prostaglandin-endoperoxide synthase 1
ASPMNM_018123−2.13Abnormal spindle (asp) homolog, microcephaly associated
GLMNAA814383−2.11Glomulin, FKBP associated protein
NASPNM_002482−2.11Nuclear autoantigenic sperm protein (histone binding)
CCNA2NM_001237−2.09Cyclin A2
TBX2AW173045−2.08T-box 2
KIF2CU63743−2.08Kinesin family member 2C
PDCD1LG2AF329193−2.06Programmed cell death 1 ligand 2
BUB1BNM_001211−2.05Budding uninhibited by benzimidazoles 1 homolog beta (yeast)
POLA1NM_016937−2.04Polymerase (DNA directed), alpha 1, catalytic subunit
TACC3NM_006342−2.02Transforming, acidic coiled-coil containing protein 3
CDK2M68520−2.01Cyclin-dependent kinase 2
DLX5NM_0052212.99Distal-less homeobox 5
VCAM1NM_0010782.88Vascular cell adhesion molecule 1
ADORA1NM_0006742.48Adenosine A1 receptor
TNFRSF9NM_0015612.38Tumor necrosis factor receptor superfamily, member 9
FGF9NM_0020102.38Fibroblast growth factor 9 (glia-activating factor)
FABP3NM_0041022.24Fatty acid binding protein 3, muscle, and heart
FGFR2M877712.20Fibroblast growth factor receptor 2
BAMBINM_0123422.13BMP and activin membrane-bound inhibitor homolog
CD24L339302.09CD24 molecule
HSF1AI3939372.07Heat shock transcription factor 1

OssificationCOL13A1M33653−3.39Collagen, type XIII, alpha 1
SATB2AK025127−3.13SATB homeobox 2
ADRB2NM_000024−2.41Adrenergic, beta-2, receptor, surface
SMAD1NM_015583−2.19SMAD family member 1
ENPP1BF591996−2.02Ectonucleotide pyrophosphatase/phosphodiesterase 1
BMPR1BAA935461−1.93Bone morphogenetic protein receptor, type IB
NAB1AF045452−1.87NGFI-A-binding protein 1 (EGR1-binding protein 1)
GNASAA810695−1.86GNAS complex locus
FGF18BC006245−1.73Fibroblast growth factor 18
TNFRSF11AAW026379−1.67Tumor necrosis factor receptor superfamily, member 11a
EGFRK03193−1.61Epidermal growth factor receptor
PLA2G4AM68874−1.61Phospholipase A2, group IVA (cytosolic, calcium dependent)
ANKHT99215−1.60Ankylosis, progressive homolog (mouse)
DLX5NM_0052212.99Distal-less homeobox 5
FGF9NM_0020102.38Fibroblast growth factor 9 (glia-activating factor)
IGFBP5R735541.78Insulin-like growth factor-binding protein 5
GABBR1N452281.72Gamma-aminobutyric acid (GABA) B receptor, 1
MMP14NM_0049951.72Matrix metallopeptidase 14 (membrane inserted)
TUFT1NM_0201271.66Tuftelin 1
COL1A1AI7436211.62Collagen, type I, alpha 1
MGPNM_0009001.61Matrix Gla protein
SMAD3BF9714161.60SMAD family member 3

BMP signaling pathwayUBE2D3AI239832−2.44Ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast)
ZFYVE16BC032227−2.43Zinc finger, FYVE domain containing 16
SMAD4AL832789−2.23SMAD family member 4
SMAD1NM_015583−2.19SMAD family member 1
BMPR1BAA935461−1.93Bone morphogenetic protein receptor, type IB
HIPK2AW300045−1.91Homeodomain interacting protein kinase 2
MSX1AI421295−1.84Msh homeobox 1
GREM2NM_022469−1.73Gremlin 2, cysteine knot superfamily, homolog (Xenopus laevis)

Prostaglandin metabolic processPTGS1NM_000962−2.13Prostaglandin-endoperoxide synthase 1
AKR1C2BF508244−1.91Aldo-keto reductase family 1, member C2
PLA2G4AM68874−1.61Phospholipase A2, group IVA (cytosolic, calcium dependent)
PTGS2NM_0009631.33 Prostaglandin-endoperoxide synthase 2
PTGISD381451.79Prostaglandin I2 (prostacyclin) synthase
PDPNAW5901961.61Podoplanin

Response to woundingTHBDAW119113−4.24Thrombomodulin
PLATNM_000930−3.12Plasminogen activator, tissue
TFPIJ03225−2.66Tissue factor pathway inhibitor
TFPI2AL574096−2.38Tissue factor pathway inhibitor 2
SDC1NM_002997−2.38Syndecan 1
SMAD1NM_015583−2.19SMAD family member 1
PLAURAY029180−1.94Plasminogen activator, urokinase receptor
TMPRSS6AI9120861.96Transmembrane protease, serine 6
JUBNM_0328761.92Jub, ajuba homolog (Xenopus laevis)

Negative number indicates decreased expression and positive number indicates elevated expression (fold change) in PC-treated OA meniscal cells compared with untreated OA meniscal cells.