Aldose Reductase Inhibitory Activity of Compounds from  Zea mays L.

Table 1

Inhibitory effects of the kernel of Zea mays L. extracts on rat lens aldose reductase (RLAR).

Extracts and fractions	Concentration (μg/mL)	Inhibition (%)	IC50 (μg/mL)
Purple corn EtOH ext.	10	62.46
	5	39.0	6.72
	1	3.18
Purple corn polyphenol extracts (PCPEs)	10	78.53
	5	58.18	3.72
	1	12.37
PCPE—hexane fr.	10	66.13
	5	39.13	7.28
	1	5.85
PCPE—methylene chloride fr.	10	71.09
	5	53.85	4.30
	1	13.38
PCPE—ethyl acetate fr.	5	71.91
	1	32.88	2.06
	0.5	13.84
PCPE—𝑛-butanol fr.	10	30.19	>10
PCPE—water fr.	10	20.61	>10
Quercetin^a	10	82.99
	5	67.91	2.34
	1	30.34

Inhibition rate was calculated as percentage with respect to the control value and expressed as mean of triplicate experiments. The concentration of each test sample giving rise to 50% inhibition of activity (IC₅₀) was estimated from the least-squares regression line of the logarithmic concentration plotted against inhibitory activity. ^aQuercetin was used as positive control.