- About this Journal
- Abstracting and Indexing
- Aims and Scope
- Annual Issues
- Article Processing Charges
- Articles in Press
- Author Guidelines
- Bibliographic Information
- Citations to this Journal
- Contact Information
- Editorial Board
- Editorial Workflow
- Free eTOC Alerts
- Publication Ethics
- Reviewers Acknowledgment
- Submit a Manuscript
- Subscription Information
- Table of Contents
BioMed Research International
Volume 2013 (2013), Article ID 729349, 11 pages
Antibodies against Food Antigens in Patients with Autistic Spectrum Disorders
1CIRANAD, Second University of Naples, via Pansini 5, Building 3, 80131 Naples, Italy
2“Alimenti e Salute” PhD School, CIRANAD, Second University of Naples, via Pansini 5, Building 3, 80131 Naples, Italy
3Department of Experimental Medicine, Second University of Naples and Centre for Autism, La Forza del Silenzio, via S. Maria di Costantinopoli 16, 80138 Naples, Italy
4Department of Mental and Physical Health and Preventive Medicine, Second University of Naples, Largo Madonna delle Grazie 1, 80138 Naples, Italy
5Department of General Pathology, Second University of Naples, Larghetto S. Aniello a Caponapoli 2, 80138 Naples, Italy
6Center for Celiac Research and Mucosal Immunology and Biology Research Center, Massachusetts General Hospital East, Charlestown, MA 02129-4404, USA
7Department of Experimental Medicine, Second University of Naples, via S. Maria di Costantinopoli 16, 80138 Naples, Italy
8UOC Clinical and Molecular Pathology, Second University of Naples, via S. Maria di Costantinopoli 16, 80138 Naples, Italy
9Department of Psychiatry, University of Catanzaro “Magna Graecia”, via T. Campanella, 88100 Catanzaro, Italy
10Department of Woman, Children and of General and Specialistic Surgery, Second University of Naples, via L. De Crecchio 4, 80138 Naples, Italy
11Department of Medical Translational Science, University of Naples “ Federico II ”, via Pansini 5, 80131 Naples, Italy
Received 21 April 2013; Revised 18 June 2013; Accepted 27 June 2013
Academic Editor: David Bernardo
Copyright © 2013 Laura de Magistris et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- C. P. Johnson, S. M. Myers, P. H. Lipkin et al., “Identification and evaluation of children with autism spectrum disorders,” Pediatrics, vol. 120, no. 5, pp. 1183–1215, 2007.
- D. B. Campbell, J. S. Sutcliffe, P. J. Ebert et al., “A genetic variant that disrupts MET transcription is associated with autism,” Proceedings of the National Academy of Sciences of the United States of America, vol. 103, no. 45, pp. 16834–16839, 2006.
- R. Sacco, P. Curatolo, B. Manzi et al., “Principal pathogenetic components and biological endophenotypes in autism spectrum disorders,” Autism Research, vol. 3, no. 5, pp. 237–252, 2010.
- R. Sacco, C. Lenti, M. Saccani et al., “Cluster analysis of autistic patients based on principal pathogenetic components,” Autism Research, vol. 5, no. 2, pp. 137–147, 2012.
- T. C. Theoharides, R. Doyle, K. Francis, P. Conti, and D. Kalogeromitros, “Novel therapeutic targets for autism,” Trends in Pharmacological Sciences, vol. 29, no. 8, pp. 375–382, 2008.
- C. G. M. de Theije, J. Wu, S. L. da Silva et al., “Pathways underlying the gut-to-brain connection in autism spectrum disorders as future targets for disease management,” European Journal of Pharmacology, vol. 668, supplement 1, pp. S70–S80, 2011.
- T. Buie, D. B. Campbell, G. J. Fuchs III et al., “Evaluation, diagnosis, and treatment of gastrointestinal disorders in individuals with ASDs: a consensus report,” Pediatrics, vol. 125, supplement 1, pp. S1–S18, 2010.
- L. de Magistris, V. Familiari, A. Pascotto et al., “Alterations of the intestinal barrier in patients with autism spectrum disorders and in their first-degree relatives,” Journal of Pediatric Gastroenterology and Nutrition, vol. 51, no. 4, pp. 418–424, 2010.
- C. Millward, M. Ferriter, S. Calver, and G. Connell-Jones, “Gluten- and casein-free diets for autistic spectrum disorder,” Cochrane Database of Systematic Reviews, no. 2, Article ID CD003498, 2004.
- C. L. Hsu, C. Y. Lin, C. L. Chen, C. M. Wang, and M. K. Wong, “The effects of a gluten and casein-free diet in children with autism: a case report,” Chang Gung Medical Journal, vol. 32, no. 4, pp. 459–465, 2009.
- P. Whiteley, D. Haracopos, A.-M. Knivsberg et al., “The ScanBrit randomised, controlled, single-blind study of a gluten- and casein-free dietary intervention for children with autism spectrum disorders,” Nutritional Neuroscience, vol. 13, no. 2, pp. 87–100, 2010.
- C. M. Pennesi and L. C. Klein, “Effectiveness of the gluten-free, casein-free diet for children diagnosed with autism spectrum disorder: based on parental report,” Nutritional Neuroscience, vol. 15, no. 2, pp. 85–91, 2012.
- S. Gupta, D. Samra, and S. Agrawal, “Adaptive and innate immune responses in autism: rationale for therapeutic use of intravenous immunoglobulin,” Journal of Clinical Immunology, vol. 30, no. 1, pp. S90–S96, 2010.
- C. Onore, M. Careaga, and P. Ashwood, “The role of immune dysfunction in the pathophysiology of autism,” Brain, Behavior, and Immunity, vol. 26, no. 3, pp. 383–392, 2012.
- J. Wasilewska, M. Kaczmarski, A. Stasiak-Barmuta, J. Tobolczyk, and E. Kowalewska, “Low serum IgA and increased expression of CD23 on B lymphocytes in peripheral blood in children with regressive autism aged 3–6 years old,” Archives of Medical Science, vol. 8, pp. 324–331, 2012.
- M. L. Castellani, C. M. Conti, D. J. Kempuraj et al., “Autism and immunity: revisited study,” International Journal of Immunopathology and Pharmacology, vol. 22, no. 1, pp. 15–19, 2009.
- B. Bakkaloglu, B. Anlar, F. Y. Anlar et al., “Atopic features in early childhood autism,” European Journal of Paediatric Neurology, vol. 12, no. 6, pp. 476–479, 2008.
- H. Jyonouchi, L. Geng, A. Ruby, C. Reddy, and B. Zimmerman-Bier, “Evaluation of an association between gastrointestinal symptoms and cytokine production against common dietary proteins in children with autism spectrum disorders,” Journal of Pediatrics, vol. 146, no. 5, pp. 605–610, 2005.
- P. Ashwood and A. J. Wakefield, “Immune activation of peripheral blood and mucosal CD3+ lymphocyte cytokine profiles in children with autism and gastrointestinal symptoms,” Journal of Neuroimmunology, vol. 173, no. 1, pp. 126–134, 2006.
- H. Jyonouchi, S. Sun, and N. Itokazu, “Innate immunity associated with inflammatory responses and cytokine production against common dietary proteins in patients with autism spectrum disorder,” Neuropsychobiology, vol. 46, no. 2, pp. 76–84, 2002.
- A. Vojdani, T. O'Bryan, J. A. Green et al., “Immune response to dietary proteins, gliadin and cerebellar peptides in children with autism,” Nutritional Neuroscience, vol. 7, no. 3, pp. 151–161, 2004.
- S. Lucarelli, T. Frediani, A. M. Zingoni et al., “Food allergy and infantile autism,” Panminerva Medica, vol. 37, no. 3, pp. 137–141, 1995.
- S. J. Genuis, “Sensitivity-related illness: the escalating pandemic of allergy, food intolerance and chemical sensitivity,” Science of the Total Environment, vol. 408, no. 24, pp. 6047–6061, 2010.
- American Psychiatric Association, Diagnostic and Statistical Manual of Mental Disorders, American Psychiatric Association, Washington, DC, USA, 4th edition, 2000.
- C. Lord, M. Rutter, and A. Le Couteur, “Autism diagnostic interview-revised: a revised version of a diagnostic interview for caregivers of individuals with possible pervasive developmental disorders,” Journal of Autism and Developmental Disorders, vol. 24, no. 5, pp. 659–685, 1994.
- E. Schopler, R. J. Reichler, and B. R. Renner, The Childhood Autism Rating Scale (CARS), Western Psychological Service, Los Angeles, Calif, USA, 1988.
- C. Lord, S. Risi, L. Lambrecht et al., “The autism diagnostic observation schedule-generic: a standard measure of social and communication deficits associated with the spectrum of autism,” Journal of Autism and Developmental Disorders, vol. 30, no. 3, pp. 205–223, 2000.
- M. Generoso, M. de Rosa, R. de Rosa et al., “Cellobiose and lactulose coupled with mannitol and determined using ion-exchange chromatography with pulsed amperometric detection, are reliable probes for investigation of intestinal permeability,” Journal of Chromatography B, vol. 783, no. 2, pp. 349–357, 2003.
- P. D'Eufemia, M. Celli, R. Finocchiaro et al., “Abnormal intestinal permeability in children with autism,” Acta Paediatrica, vol. 85, no. 9, pp. 1076–1079, 1996.
- S. Amarri, P. Alvisi, R. DeGiorgio et al., “Antibodies to deamidated gliadin peptides: an accurate predictor of celiac disease in infancy,” Journal of Clinical Immunology, vol. 33, no. 5, pp. 1027–1030, 2013.
- A. Cerutti, “The regulation of IgA class switching,” Nature Reviews Immunology, vol. 8, no. 6, pp. 421–434, 2008.
- J. W. Critchfield, S. van Hemert, M. Ash, L. Mulder, and P. Ashwood, “The potential role of probiotics in the management of childhood autism spectrum disorders,” Gastroenterology Research and Practice, vol. 2011, Article ID 161358, 8 pages, 2011.
- B. L. Williams, M. Hornig, T. Buie et al., “Impaired carbohydrate digestion and transport and mucosal dysbiosis in the intestines of children with autism and gastrointestinal disturbances,” PLoS ONE, vol. 6, no. 9, Article ID e24585, 2011.
- D. Siniscalco, A. Sapone, C. Giordano et al., “The expression of caspases is enhanced in peripheral blood mononuclear cells of autism spectrum disorder patients,” Journal of Autism and Developmental Disorders, vol. 42, no. 7, pp. 1403–1410, 2012.
- A. Fasano, “Zonulin and its regulation of intestinal barrier function: the biological door to inflammation, autoimmunity, and cancer,” Physiological Reviews, vol. 91, no. 1, pp. 151–175, 2011.
- A. Angelidou, K. Francis, M. Vasiadi et al., “Neurotensin is increased in serum of young children with autistic disorder,” Journal of Neuroinflammation, vol. 7, article 48, 2010.
- A. Angelidou, S. Asadi, K. D. Alysandratos, A. Karagkouni, S. Kourembanas, and T. C. Theoharides, “Perinatal stress, brain inflammation and the risk of autism,” BCM Pediatrics, vol. 12, article 89, 2012.
- L. Pavone, A. Fiumara, G. Bottaro, D. Mazzone, and M. Coleman, “Autism and celiac disease: failure to validate the hypothesis that a link might exist,” Biological Psychiatry, vol. 42, no. 1, pp. 72–75, 1997.
- I. C. Batista, L. Gandolfi, Y. K. M. Nobrega et al., “Autism spectrum disorder and celiac disease: no evidence for a link,” Arquivos de Neuro-Psiquiatria, vol. 70, no. 1, pp. 28–33, 2012.
- J. R. Biesiekierski, E. D. Newnham, P. M. Irving et al., “Gluten causes gastrointestinal symptoms in subjects without celiac disease: a double-blind randomized placebo-controlled trial,” American Journal of Gastroenterology, vol. 106, no. 3, pp. 508–514, 2011.
- A. Sapone, K. M. Lammers, V. Casolaro et al., “Divergence of gut permeability and mucosal immune gene expression in two gluten-associated conditions: celiac disease and gluten sensitivity,” BMC Medicine, vol. 9, article 23, 2011.
- A. Sapone, J. C. Bai, C. Ciacci et al., “Spectrum of gluten-related disorders: consensus on new nomenclature and classification,” BMC Medicine, vol. 10, article 13, 2012.