CD59 Underlines the Antiatherosclerotic Effects of C-Phycocyanin on Mice
Figure 5
CDK4 mRNA levels in different groups of mice. (a) CDK4 mRNA levels by in situ hybridization (). The positive cell nucleus was dyed brownish yellow. The color in aortic plaque arose from smooth muscle cells was dark and CDK4 mRNA levels were high in control group. In C-PC treatment group and CD59 transfection group, the nucleus color was lighter and brownish-yellow granules were less than those in control group. Moreover, the color was the lightest and staining intensity was the weakest in C-PC+CD59 synergy group. (A) Control group, (B) C-PC treatment group, (C) CD59 transfection group, and (D) C-PC+CD59 synergy group. (b) IOD values of different groups of mice. *, ** versus control group. IOD values represent the levels of protein expression. Compared with the control group, the IOD values in CD59 or C-PC treated groups were decreased and the differences were significant (*). The IOD values were further enhanced in C-PC and CD59 synergy group and the differences were very significant (**).
