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BioMed Research International
Volume 2013 (2013), Article ID 729413, 15 pages
http://dx.doi.org/10.1155/2013/729413
Research Article

CD59 Underlines the Antiatherosclerotic Effects of C-Phycocyanin on Mice

1Department of Biology, Medical College of Qingdao University, 38 Dengzhou Road, Qingdao 266021, China
2Department of Cardiology, Affiliated Hospital of Medical College of Qingdao University, Qingdao 266100, China
3Department of Neurological Function Inspection, Affiliated Hospital of Medical College of Qingdao University, Qingdao 266100, China

Received 5 July 2013; Revised 23 September 2013; Accepted 27 September 2013

Academic Editor: Senthil K. Venugopal

Copyright © 2013 Bing Li et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. J. Guo, H. Z. Li, L. C. Wang et al., “Increased expression of calcium-sensing receptors in atherosclerosis confers hypersensitivity to acute myocardial infarction in rats,” Molecular and Cellular Biochemistry, vol. 366, no. 1-2, pp. 345–354, 2012. View at Publisher · View at Google Scholar · View at Scopus
  2. A. C. Elkan, C. Anania, T. Gustafsson, T. Jogestrand, I. Hafstrom, and J. Frostegard, “Diet and fatty acid pattern among patients with SLE: associations with disease activity, blood lipids and atherosclerosis,” Lupus, vol. 21, no. 13, pp. 1405–1411.
  3. Z. Shan, C. Yao, Z. L. Li et al., “Differentially expressed microRNAs at different stages of atherosclerosis in ApoE-deficient mice,” Chinese Medical Journal, vol. 126, no. 3, pp. 515–520, 2013.
  4. D. G. Zacharias, S. G. Kim, A. E. Massat et al., “Humanin, a cytoprotective peptide, is expressed in carotid artherosclerotic plaques in humans,” PLoS ONE, vol. 7, no. 2, Article ID e31065, 2012. View at Publisher · View at Google Scholar · View at Scopus
  5. J. Acosta, X. Qin, and J. Halperin, “Complement and complement regulatory proteins as potential molecular targets for vascular diseases,” Current Pharmaceutical Design, vol. 10, no. 2, pp. 203–211, 2004. View at Publisher · View at Google Scholar · View at Scopus
  6. F. Niculescu, T. Badea, and H. Rus, “Sublytic C5b-9 induces proliferation of human aortic smooth muscle cells: role of mitogen activated protein kinase and phosphatidylinositol 3-kinase,” Atherosclerosis, vol. 142, no. 1, pp. 47–56, 1999. View at Publisher · View at Google Scholar · View at Scopus
  7. H. G. Rus, F. Niculescu, E. Constantinescu, A. Cristea, and R. Vlaicu, “Immunoelectron-microscopic localization of the terminal C5b-9 complement complex in human atherosclerotic fibrous plaque,” Atherosclerosis, vol. 61, no. 1, pp. 35–42, 1986. View at Scopus
  8. S. Yun, V. W. Y. Leung, M. Botto, J. J. Boyle, and D. O. Haskard, “Brief report: accelerated atherosclerosis in low-density lipoprotein receptor-deficient mice lacking the membrane-bound complement regulator CD59,” Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 28, no. 10, pp. 1714–1716, 2008. View at Publisher · View at Google Scholar · View at Scopus
  9. S. Baalasubramanian, C. L. Harris, R. M. Donev et al., “CD59a is the primary regulator of membrane attack complex assembly in the mouse,” Journal of Immunology, vol. 173, no. 6, pp. 3684–3692, 2004. View at Scopus
  10. R. M. Donev, B. Sivasankar, M. Mizuno, and B. P. Morgan, “The mouse complement regulator CD59b is significantly expressed only in testis and plays roles in sperm acrosome activation and motility,” Molecular Immunology, vol. 45, no. 2, pp. 534–542, 2008. View at Publisher · View at Google Scholar · View at Scopus
  11. X. Qin, S. Ferris, W. Hu, F. Guo, G. Ziegeler, and J. A. Halperin, “Analysis of the promoters and 5′-UTR of mouse Cd59 genes, and of their functional activity in erythrocytes,” Genes and Immunity, vol. 7, no. 4, pp. 287–297, 2006. View at Publisher · View at Google Scholar · View at Scopus
  12. X. Qin, W. Hu, W. Song et al., “Generation and phenotyping of mCd59a and mCd59b double-knockout mice,” The American Journal of Hematology, vol. 84, no. 2, pp. 65–70, 2009. View at Publisher · View at Google Scholar · View at Scopus
  13. X. Qin, N. Krumrei, L. Grubissich et al., “Deficiency of the mouse complement regulatory protein mCd59b results in spontaneous hemolytic anemia with platelet activation and progressive male infertility,” Immunity, vol. 18, no. 2, pp. 217–227, 2003. View at Publisher · View at Google Scholar · View at Scopus
  14. D. S. Holt, M. Botto, A. E. Bygrave, S. M. Hanna, M. J. Walport, and B. Paul Morgan, “Targeted deletion of the CD59 gene causes spontaneous intravascular hemolysis and hemoglobinuria,” Blood, vol. 98, no. 2, pp. 442–449, 2001. View at Publisher · View at Google Scholar · View at Scopus
  15. A. N. Glazer, “S β-(Bilin)cystein derivatives: structures, spectroscopic properties, and quantitation,” Methods in Enzymology, vol. 106, pp. 359–364, 1984. View at Publisher · View at Google Scholar · View at Scopus
  16. B. Li, X. Zhang, M. Gao, and X. Chu, “Effects of CD59 on antitumoral activities of phycocyanin from Spirulina platensis,” Biomedicine and Pharmacotherapy, vol. 59, no. 10, pp. 551–560, 2005. View at Publisher · View at Google Scholar · View at Scopus
  17. M. S. Miranda, R. G. Cintra, S. B. M. Barros, and J. Mancini-Filho, “Antioxidant activity of the microalga Spirulina maxima,” Brazilian Journal of Medical and Biological Research, vol. 31, no. 8, pp. 1075–1079, 1998. View at Scopus
  18. G. Chamorro, M. Salazar, L. Favila, and H. Bourges, “Pharmacology and toxicology of spirulina alga,” Revista de Investigacion Clinica, vol. 48, no. 5, pp. 389–399, 1996. View at Scopus
  19. R. Thangam, V. Suresh, W. Asenath Princy et al., “C-Phycocyanin from Oscillatoria tenuis exhibited an antioxidant and in vitro antiproliferative activity through induction of apoptosis and G0/G1 cell cycle arrest,” Food Chemistry, vol. 140, no. 1-2, pp. 262–272, 2013. View at Publisher · View at Google Scholar
  20. S. Ayehunie, A. Belay, T. W. Baba, and R. M. Ruprecht, “Inhibition of HIV-1 replication by an aqueous extract of Spirulina platensis (Arthrospira platensis),” Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology, vol. 18, no. 1, pp. 7–12, 1998. View at Scopus
  21. H. M. Kim, E. H. Lee, H. H. Cho, and Y. H. Moon, “Inhibitory effect of mast cell-mediated immediate-type allergic reactions in rats by spirulina,” Biochemical Pharmacology, vol. 55, no. 7, pp. 1071–1076, 1998. View at Publisher · View at Google Scholar · View at Scopus
  22. C. G. de Rivera, R. Miranda-Zamora, J. C. Diaz-Zagoya, and J. Juarez-Oropeza, “preventive effect of Spirulina maxima on the fatty liver induced by a fructose-rich diet in the rat, a preliminary report,” Life Sciences, vol. 53, no. 1, pp. 57–61, 1993. View at Publisher · View at Google Scholar · View at Scopus
  23. B. Li, M. H. Gao, X. C. Zhang, and X. M. Chu, “Molecular immune mechanism of C-phycocyanin from Spirulina platensis induces apoptosis in HeLa cells in vitro,” Biotechnology and Applied Biochemistry, vol. 43, no. 3, pp. 155–164, 2006. View at Publisher · View at Google Scholar · View at Scopus
  24. S. M. M. Shanab, S. S. M. Mostafa, E. A. Shalaby, and G. I. Mahmoud, “Aqueous extracts of microalgae exhibit antioxidant and anticancer activities,” Asian Pacific Journal of Tropical Biomedicine, vol. 2, no. 8, pp. 608–615, 2012. View at Publisher · View at Google Scholar · View at Scopus
  25. C. Romay, N. Ledón, and R. González, “Further studies on anti-inflammatory activity of phycocyanin in some animal models of inflammation,” Inflammation Research, vol. 47, no. 8, pp. 334–338, 1998. View at Publisher · View at Google Scholar · View at Scopus
  26. B. Li, X. Chu, M. Gao, and W. Li, “Apoptotic mechanism of MCF-7 breast cells in vivo and in vitro induced by photodynamic therapy with C-phycocyanin,” Acta Biochimica et Biophysica Sinica, vol. 42, no. 1, pp. 80–89, 2010. View at Publisher · View at Google Scholar · View at Scopus
  27. M. C. Paredes-Carbajal, P. V. Torres-Durán, J. C. Díaz-Zagoya, D. Mascher, and M. A. Juárez-Oropeza, “Effects of dietary Spirulina maxima on endothelium dependent vasomotor responses of rat aortic rings,” Life Sciences, vol. 61, no. 15, pp. PL211–PL219, 1997. View at Publisher · View at Google Scholar · View at Scopus
  28. K. Iwata, T. Inayama, and T. Kato, “Effects of Spirulina platensis on plasma lipoprotein lipase activity in fructose-induced hyperlipidemic rats,” Journal of Nutritional Science and Vitaminology, vol. 36, no. 2, pp. 165–171, 1990. View at Scopus
  29. J. M. Li, M. H. Gao, and B. Zhang, “Inhibition of mutant CD59 protein on proliferation of ovarian cancer A2780 cells,” Ai Zheng, vol. 28, no. 4, pp. 379–383, 2009. View at Scopus
  30. R. Ross, “Atherosclerosis—an inflammatory disease,” The New England Journal of Medicine, vol. 340, no. 2, pp. 115–126, 1999. View at Publisher · View at Google Scholar · View at Scopus
  31. W. Kong and Y. Zhu, “The pleiotropic effects of statins in the prevention of atherosclerosis: editorial to: “simvastatin suppresses apoptosis in vulnerable atherosclerotic plaques through regulating the expression of p53, Bcl-2 en Bcl-xL” by Weiwei Qin et al.,” Cardiovascular Drugs and Therapy, vol. 26, no. 1, pp. 5–7, 2012. View at Publisher · View at Google Scholar · View at Scopus
  32. B. Li, X. Chu, M. Gao, and Y. Xu, “The effects of CD59 gene as a target gene on breast cancer cells,” Cellular Immunology, vol. 272, no. 1, pp. 61–70, 2011. View at Publisher · View at Google Scholar · View at Scopus
  33. M. Vernhes, M. Gonzalez-Pumariega, L. Andrade et al., “Protective effect of a Phyllanthus orbicularis aqueous extract against UVB light in human cells,” Pharmaceutical Biology, vol. 51, no. 1, pp. 1–7, 2013. View at Publisher · View at Google Scholar
  34. H. Yano, A. Mizoguchi, K. Fukuda et al., “The herbal medicine sho-saiko-to inhibits proliferation of cancer cell lines by inducing apoptosis and arrest at the G0/G1 phase,” Cancer Research, vol. 54, no. 2, pp. 448–454, 1994. View at Scopus
  35. R. Grobholz, H. Zentgraf, K. U. Köhrmann, and U. Bleyl, “Bax, Bcl-2, Fas and Fas-L antigen expression in human seminoma: correlation with the apoptotic index,” APMIS, vol. 110, no. 10, pp. 724–732, 2002. View at Publisher · View at Google Scholar · View at Scopus
  36. X. Zhao, J. Q. Du, D. Y. Xu, and S. P. Zhao, “Effects of soluble epoxide hydrolase inhibitor on the expression of fatty acid synthase in peripheral blood mononuclear cell in patients with acute coronary syndrome,” Lipids in Health and Disease, vol. 12, no. 1, article 3, 2013. View at Publisher · View at Google Scholar
  37. S. Shirali, M. Aghaei, M. Shabani, M. Fathi, M. Sohrabi, and M. Moeinifard, “Adenosine induces cell cycle arrest and apoptosis via cyclinD1/Cdk4 and Bcl-2/Bax pathways in human ovarian cancer cell line OVCAR-3,” Tumor Biology, vol. 34, no. 2, pp. 1085–1095, 2013. View at Publisher · View at Google Scholar
  38. B. V. V. Pardhasaradhi, A. M. Ali, A. L. Kumari, P. Reddanna, and A. Khar, “Phycocyanin-mediated apoptosis in AK-5 tumor cells involves down-regulation of Bcl-2 and generation of ROS,” Molecular Cancer Therapeutics, vol. 2, no. 11, pp. 1165–1170, 2003. View at Scopus
  39. R. Karki, O. M. Ho, and D. W. Kim, “Magnolol attenuates neointima formation by inducing cell cycle arrest via inhibition of ERK1/2 and NF-kappaB activation in vascular smooth muscle cells,” Biochimica et Biophysica Acta, vol. 1830, no. 3, pp. 2619–2628, 2013.
  40. B. K. Choi, B. Y. Cha, T. Yagyu, J. T. Woo, and M. Ojika, “Sponge-derived acetylenic alcohols, petrosiols, inhibit proliferation and migration of platelet-derived growth factor (PDGF)-induced vascular smooth muscle cells,” Bioorganic and Medicinal Chemistry, vol. 21, no. 7, pp. 1804–1810, 2013. View at Publisher · View at Google Scholar
  41. S. Yongxin, D. Wenjun, W. Qiang, S. Yunqing, Z. Liming, and W. Chunsheng, “Heavy smoking before coronary surgical procedures affects the native matrix metalloproteinase-2 and matrix metalloproteinase-9 gene expression in saphenous vein conduits,” Annals of Thoracic Surgery, vol. 95, no. 1, pp. 55–61, 2013. View at Publisher · View at Google Scholar
  42. S. B. Jeon, S. Chun, S. Choi-Kwon et al., “Biomarkers and location of atherosclerosis: matrix metalloproteinase-2 may be related to intracranial atherosclerosis,” Atherosclerosis, vol. 223, no. 2, pp. 442–447, 2012. View at Publisher · View at Google Scholar