Tight Junction Proteins and Oxidative Stress in Heavy Metals-Induced Nephrotoxicity
Figure 4
Comparative claudin 5 distribution in tubules and vessels in kidney from a control rat and a dam rat intoxicated with Cd during pregnancy. In renal sections from a normal dam rat claudin 5 (green label) costained with VE-cadherin (red label) is expressed in glomerular capillaries (arrow heads (a)) and in surrounding vessels (arrow, (a)). Expression of claudin 5 at the glomerular capillaries (arrow heads, (b)) and in surrounding vessels (arrow, (b)) is severely altered in a dam rat exposed to Cd. Bar = 50 μm.
