Suppression of Osteopontin Functions by Levocetirizine, a Histamine Receptor Antagonist, In Vitro
Figure 2
Influence of antihistamines on TNF-α-induced osteopontin (OPN) production from nasal epithelial cells in vitro. Nasal epithelial cells obtained from five different subjects were stimulated with 10 ng/mL TNF-α in the presence of various concentrations of CT, LCT, DL and FEX for 24 h. OPN levels in culture supernatants were examined by ELISA. *Significant () versus control; (a) cetirizine (CT); (b) levocetirizine (LCT); (c) desloratadine (DL); (d) fexofenadine (FEX).
