TrkAIII Promotes Microtubule Nucleation and Assembly at the Centrosome in SH-SY5Y Neuroblastoma Cells, Contributing to an Undifferentiated Anaplastic Phenotype
Figure 2
(a) Representative IF images comparing TrkA variant expression (green), α-tubulin positive MTs (red), and the overlap (yellow/orange) in untreated and CEP-701-treated (100 ng overnight) TrkAIII SH-SY5Y transfectants and in untreated kd-TrkAIII, TrkAI, and control pcDNA SH-SY5Y transfectants. (b) Representative IF images comparing the pattern of TrkAIII expression (green), TrkAIII-associated tyrosine phosphorylation (red), and overlap (yellow/orange) in untreated and CEP-701-treated (100 nM, overnight) TrkAIII SH-SY5Y transfectants.
