About this Journal Submit a Manuscript Table of Contents
BioMed Research International
Volume 2013 (2013), Article ID 740195, 5 pages
http://dx.doi.org/10.1155/2013/740195
Clinical Study

Diffusion-Weighted Magnetic Resonance Application in Response Prediction before, during, and after Neoadjuvant Radiochemotherapy in Primary Rectal Cancer Carcinoma

1Department of Radiotherapy, Policlinico Umberto I “Sapienza” University of Rome, Viale Regina Elena 326, 00161 Rome, Italy
2Department of Radiological Sciences, Oncology and Pathology, Policlinico Umberto I “Sapienza” University of Rome, Polo Pontino, Corso della Repubblica 79, 04100 Latina, Italy
3Department of Surgical Sciences, Policlinico Umberto I “Sapienza” University of Rome, Viale Regina Elena 326, 00161 Rome, Italy
4Spencer-Lorillard Foundation, Viale Regina Elena 291, 00161 Rome, Italy

Received 16 May 2013; Accepted 24 June 2013

Academic Editor: Aleksandra Nikolic

Copyright © 2013 Daniela Musio et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. F. Bonnetain, J. F. Bosset, J. P. Gerard et al., “What is the clinical benefit of preoperative chemoradiotherapy with 5FU/leucovorin for T3-4 rectal cancer in a pooled analysis of EORTC 22921 and FFCD 9203 trials: surrogacy in question?” European Journal of Cancer, vol. 48, no. 12, pp. 1781–1790, 2012. View at Publisher · View at Google Scholar · View at Scopus
  2. H. J. Schmoll, E. Van Cutsem, A. Stein, et al., “ESMO Consensus Guidelines for management of patients with colon and rectal cancer. A personalized approach to clinical decision making,” Annals of Oncology, vol. 23, no. 10, pp. 2479–2516, 2012.
  3. A. Habr-Gama, R. O. Perez, W. Nadalin et al., “Operative versus nonoperative treatment for stage 0 distal rectal cancer following chemoradiation therapy: long-term results,” Annals of Surgery, vol. 240, no. 4, pp. 711–718, 2004. View at Publisher · View at Google Scholar · View at Scopus
  4. H. C. Thoeny and B. D. Ross, “Predicting and monitoring cancer treatment response with diffusion-weighted MRI,” Journal of Magnetic Resonance Imaging, vol. 32, no. 1, pp. 2–16, 2010. View at Publisher · View at Google Scholar
  5. D. M. Koh and D. J. Collins, “Diffusion-weighted MRI in the body: applications and challenges in oncology,” American Journal of Roentgenology, vol. 188, no. 6, pp. 1622–1635, 2007.
  6. D. Musio, F. De Felice, N. Bulzonetti, et al., “Neoadjuvant-intensified treatment for rectal cancer: time to change?” World Journal of Gastroenterology, vol. 19, no. 20, Article ID 237169, pp. 3052–3061, 2013. View at Publisher · View at Google Scholar
  7. D. Le Bihan, E. Breton, D. Lallemand, M.-L. Aubin, J. Vignaud, and M. Laval-Jeantet, “Separation of diffusion and perfusion in intravoxel incoherent motion MR imaging,” Radiology, vol. 168, no. 2, pp. 497–505, 1988. View at Scopus
  8. C. Aschele, L. Cionini, S. Lonardi et al., “Primary tumor response to preoperative chemoradiation with or without oxaliplatin in locally advanced rectal cancer: pathologic results of the STAR-01 randomized phase III trial,” Journal of Clinical Oncology, vol. 29, no. 20, pp. 2773–2780, 2011. View at Publisher · View at Google Scholar · View at Scopus
  9. J.-P. Gérard, D. Azria, S. Gourgou-Bourgade et al., “Comparison of two neoadjuvant chemoradiotherapy regimens for locally advanced rectal cancer: results of the phase III trial accord 12/0405-Prodige 2,” Journal of Clinical Oncology, vol. 28, no. 10, pp. 1638–1644, 2010. View at Publisher · View at Google Scholar · View at Scopus
  10. R. Rödel, T. Liersch, H. Becker, et al., “Preoperative chemoradiotherapy and postoperative chemotherapy with fluorouracil and oxaliplatin versus fluorouracil alone in locally advanced rectal cancer: initial results of the German CAO/ARO/AIO-04 randomised phase 3 trial,” The Lancet Oncology, vol. 13, no. 7, pp. 679–687, 2012. View at Publisher · View at Google Scholar
  11. H. G. Moore, A. E. Gittleman, B. D. Minsky et al., “Rate of pathologic complete response with increased interval between preoperative combined modality therapy and rectal cancer resection,” Diseases of the Colon and Rectum, vol. 47, no. 3, pp. 279–286, 2004. View at Publisher · View at Google Scholar · View at Scopus
  12. Y. C. Kim, J. S. Lim, K. C. Keum et al., “Comparison of diffusion-weighted MRI and MR volumetry in the evaluation of early treatment outcomes after preoperative chemoradiotherapy for locally advanced rectal cancer,” Journal of Magnetic Resonance Imaging, vol. 34, no. 3, pp. 570–576, 2011. View at Publisher · View at Google Scholar · View at Scopus
  13. A. R. Padhani, G. Liu, D. Mu-Koh et al., “Diffusion-weighted magnetic resonance imaging as a cancer biomarker: consensus and recommendations,” Neoplasia, vol. 11, no. 2, pp. 102–125, 2009. View at Publisher · View at Google Scholar · View at Scopus
  14. M. Zhao, J. G. Pipe, J. Bonnett, and J. L. Evelhoch, “Early detection of treatment response by diffusion-weighted 1H-NMR spectroscopy in a murine tumour in vivo,” British Journal of Cancer, vol. 73, no. 1, pp. 61–64, 1996. View at Scopus
  15. D. Boone, S. A. Taylor, and S. Halligan, “Diffusion Weighted MRI: overview and implications for rectal cancer management,” Colorectal Disease, vol. 15, no. 6, pp. 655–661, 2013. View at Publisher · View at Google Scholar
  16. L. Lemaire, F. A. Howe, L. M. Rodrigues, and J. R. Griffiths, “Assessment of induced rat mammary tumour response to chemotherapy using the apparent diffusion coefficient of tissue water as determined by diffusion-weighted 1H-NMR spectroscopy in vivo,” Magnetic Resonance Materials in Physics, Biology and Medicine, vol. 8, no. 1, pp. 20–26, 1999. View at Publisher · View at Google Scholar · View at Scopus
  17. A. Dzik-Jurasz, C. Domenig, M. George et al., “Diffusion MRI for prediction of response of rectal cancer to chemoradiation,” The Lancet, vol. 360, no. 9329, pp. 307–308, 2002. View at Publisher · View at Google Scholar · View at Scopus
  18. P. A. Hein, C. Kremser, W. Judmaier et al., “Diffusion-weighted MRI—a new parameter for advanced rectal carcinoma?” RoFo Fortschritte auf dem Gebiet der Rontgenstrahlen und der Bildgebenden Verfahren, vol. 175, no. 3, pp. 381–386, 2003. View at Publisher · View at Google Scholar · View at Scopus
  19. M. Lambrecht, C. Deroose, S. Roels et al., “The use of FDG-PET/CT and diffusion-weighted magnetic resonance imaging for response prediction before, during and after preoperative chemoradiotherapy for rectal cancer,” Acta Oncologica, vol. 49, no. 7, pp. 956–963, 2010. View at Publisher · View at Google Scholar · View at Scopus
  20. C. Kremser, W. Judmaier, P. Hein, J. Griebel, P. Lukas, and A. de Vries, “Preliminary results on the influence of chemoradiation on apparent diffusion coefficients of primary rectal carcinoma measured by magnetic resonance imaging,” Strahlentherapie und Onkologie, vol. 179, no. 9, pp. 641–649, 2003. View at Publisher · View at Google Scholar · View at Scopus
  21. Y.-S. Sun, X.-P. Zhang, L. Tang et al., “Locally advanced rectal carcinoma treated with preoperative chemotherapy and radiation therapy: preliminary analysis of diffusion-weighted MR imaging for early detection of tumor histopathologic downstaging,” Radiology, vol. 254, no. 1, pp. 170–178, 2010. View at Publisher · View at Google Scholar · View at Scopus
  22. P. A. Hein, C. Kremser, W. Judmaier et al., “Diffusion-weighted magnetic resonance imaging for monitoring diffusion changes in rectal carcinoma during combined, preoperative chemoradiation: preliminary results of a prospective study,” European Journal of Radiology, vol. 45, no. 3, pp. 214–222, 2003. View at Publisher · View at Google Scholar · View at Scopus
  23. B. Barbaro, R. Vitale, V. Valentini et al., “Diffusion-weighted magnetic resonance imaging in monitoring rectal cancer response to neoadjuvant chemoradiotherapy,” International Journal of Radiation Oncology, Biology, Physics, vol. 83, no. 2, pp. 594–599, 2011. View at Publisher · View at Google Scholar · View at Scopus
  24. P. Therasse, S. G. Arbuck, E. A. Eisenhauer et al., “New guidelines to evaluate the response to treatment in solid tumors,” Journal of the National Cancer Institute, vol. 92, no. 3, pp. 205–216, 2000. View at Scopus
  25. L. M. Wu, J. Zhu, J. Hu, et al., “Is there a benefit in using magnetic resonance imaging in the prediction of preoperative neoadjuvant therapy response in locally advanced rectal cancer?” International Journal of Colorectal Disease. In press.