Prooxidant Mechanisms in Iron Overload Cardiomyopathy

Figure 2

Adiponectin ameliorates cardiac inflammation in IOC through the PPARα-PGC1-dependent signaling pathway. The schematic diagram showing that adiponectin exerts its beneficial effects in cardiomyocytes through the PPARα-dependent HO-1 signaling pathway and requires PPARα-PGC-1 interaction. The adiponectin-AdipoR2-PPARα signaling may be the major pathway in exerting anti-inflammatory and antioxidative stress effects that ameliorate iron-overload cardiac dysfunction.