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BioMed Research International
Volume 2013 (2013), Article ID 742149, 14 pages
http://dx.doi.org/10.1155/2013/742149
Review Article

Structure and Antimicrobial Properties of Monensin A and Its Derivatives: Summary of the Achievements

1Faculty of Chemistry, Jagiellonian University, Ingardena 3, 30-060 Krakow, Poland
2Department of Biochemistry, Faculty of Chemistry, Adam Mickiewicz University, Umultowska 89b, 61-614 Poznan, Poland

Received 29 August 2012; Revised 15 December 2012; Accepted 29 December 2012

Academic Editor: Ivayla Pantcheva-Kadreva

Copyright © 2013 Daniel Łowicki and Adam Huczyński. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

In this paper structural and microbiological studies on the ionophorous antibiotic monensin A and its derivatives have been collected. Monensin A is an ionophore which selectively complexes and transports sodium cation across lipid membranes, and therefore it shows a variety of biological properties. This antibiotic is commonly used as coccidiostat and nonhormonal growth promoter. The paper focuses on both the latest and earlier achievements concerning monensin A antimicrobial activity. The activities of monensin derivatives, including modifications of hydroxyl groups and carboxyl group, are also presented.