Review Article
Hereditary Breast Cancer: The Era of New Susceptibility Genes
Table 1
Criteria of target population for genetic test on customized gene panel modified from (
http://www.nccn.org/).
| Individual with breast/ovarian cancer personal history and one of the following: | | (i) breast and/or ovarian or pancreatic cancer in at least two blood relatives; | | (ii) multiple primary breast cancers or bilateral breast cancer, first diagnosed before the age of 50 years; | | (iii) premenopausal triple negative breast cancer diagnosed at a young age (<45 years); | | (iv) male breast cancer in a blood relative; | | (v) ethnicities with high BRCA mutation frequency, such as Ashkenazi Jews, should be tested, even in the absence of family history. | |
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