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BioMed Research International
Volume 2013 (2013), Article ID 747938, 8 pages
Purity and Enrichment of Laser-Microdissected Midbrain Dopamine Neurons
1Neurobiology of Ageing Laboratory, School of Biomedical Sciences and Pharmacy, Centre for Translational Neuroscience and Mental Health Research, University of Newcastle, Newcastle, NSW 2308, Australia
2Hunter Medical Research Institute, Kookaburra Circuit, New Lambton Heights, Newcastle, NSW 2305, Australia
3Faculty of Science, Engineering & Built Environment, Waurn Ponds Campus, Locked Bag 20000, Geelong, VIC 3220, Australia
Received 15 May 2013; Accepted 2 July 2013
Academic Editor: Johbu Itoh
Copyright © 2013 Amanda L. Brown et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- A. Björklund and S. B. Dunnett, “Dopamine neuron systems in the brain: an update,” Trends in Neurosciences, vol. 30, no. 5, pp. 194–202, 2007.
- S. Lammel, A. Hetzel, O. Häckel, I. Jones, B. Liss, and J. Roeper, “Unique properties of mesoprefrontal neurons within a dual mesocorticolimbic dopamine system,” Neuron, vol. 57, no. 5, pp. 760–773, 2008.
- J. Grimm, A. Mueller, F. Hefti, and A. Rosenthal, “Molecular basis for catecholaminergic neuron diversity,” Proceedings of the National Academy of Sciences of the United States of America, vol. 101, no. 38, pp. 13891–13896, 2004.
- R. G. Nair-Roberts, S. D. Chatelain-Badie, E. Benson, H. White-Cooper, J. P. Bolam, and M. A. Ungless, “Stereological estimates of dopaminergic, GABAergic and glutamatergic neurons in the ventral tegmental area, substantia nigra and retrorubral field in the rat,” Neuroscience, vol. 152, no. 4, pp. 1024–1031, 2008.
- T. Yamaguchi, W. Sheen, and M. Morales, “Glutamatergic neurons are present in the rat ventral tegmental area,” European Journal of Neuroscience, vol. 25, no. 1, pp. 106–118, 2007.
- J. Gründemann, F. Schlaudraff, O. Haeckel, and B. Liss, “Elevated α-synuclein mRNA levels in individual UV-laser-microdissected dopaminergic substantia nigra neurons in idiopathic Parkinson's disease,” Nucleic Acids Research, vol. 36, no. 7, article e38, 2008.
- S. Ikemoto, “Dopamine reward circuitry: two projection systems from the ventral midbrain to the nucleus accumbens-olfactory tubercle complex,” Brain Research Reviews, vol. 56, no. 1, pp. 27–78, 2007.
- A. L. Brown and D. W. Smith, “Improved RNA preservation for immunolabeling and laser microdissection,” RNA, vol. 15, no. 12, pp. 2364–2374, 2009.
- T. D. Schmittgen and K. J. Livak, “Analyzing real-time PCR data by the comparative CT method,” Nature Protocols, vol. 3, no. 6, pp. 1101–1108, 2008.
- R. H. Zetterström, R. Williams, T. Perlmann, and L. Olson, “Cellular expression of the immediate early transcription factors Nurr1 and NGFI-B suggests a gene regulatory role in several brain regions including the nigrostriatal dopamine system,” Molecular Brain Research, vol. 41, no. 1-2, pp. 111–120, 1996.
- Y. Chu, K. Kompoliti, E. J. Cochran, E. J. Mufson, and J. H. Kordower, “Age-related decreases in Nurr1 immunoreactivity in the human substantia nigra,” Journal of Comparative Neurology, vol. 450, no. 3, pp. 203–214, 2002.
- M. Kawano, A. Kawasaki, H. Sakata-Haga et al., “Particular subpopulations of midbrain and hypothalamic dopamine neurons express vesicular glutamate transporter 2 in the rat brain,” Journal of Comparative Neurology, vol. 498, no. 5, pp. 581–592, 2006.
- N. Gorelova, P. J. Mulholland, L. J. Chandler, and J. K. Seamans, “The glutamatergic component of the mesocortical pathway emanating from different subregions of the ventral midbrain,” Cerebral Cortex, vol. 22, no. 2, pp. 327–336, 2011.
- N. Chuhma, H. Zhang, J. Masson et al., “Dopamine neurons mediate a fast excitatory signal via their glutamatergic synapses,” Journal of Neuroscience, vol. 24, no. 4, pp. 972–981, 2004.
- A. Lavin, L. Nogueira, C. C. Lapish, R. M. Wightman, P. E. M. Phillips, and J. K. Seamans, “Mesocortical dopamine neurons operate in distinct temporal domains using multimodal signaling,” Journal of Neuroscience, vol. 25, no. 20, pp. 5013–5023, 2005.
- T. S. Hnasko, N. Chuhma, H. Zhang et al., “Vesicular glutamate transport promotes dopamine storage and glutamate corelease in vivo,” Neuron, vol. 65, no. 5, pp. 643–656, 2010.
- G. D. Stuber, T. S. Hnasko, J. P. Britt, R. H. Edwards, and A. Bonci, “Dopaminergic terminals in the nucleus accumbens but not the dorsal striatum corelease glutamate,” Journal of Neuroscience, vol. 30, no. 24, pp. 8229–8233, 2010.
- F. Tecuapetla, J. C. Patel, H. Xenias et al., “Glutamatergic signaling by mesolimbic dopamine neurons in the nucleus accumbens,” Journal of Neuroscience, vol. 30, no. 20, pp. 7105–7110, 2010.
- C. Birgner, K. Nordenankar, M. Lundblad et al., “VGLUT2 in dopamine neurons is required for psychostimulant-induced behavioral activation,” Proceedings of the National Academy of Sciences of the United States of America, vol. 107, no. 1, pp. 389–394, 2010.
- L. Descarries, N. Bérubé-Carrière, M. Riad, G. D. Bo, J. A. Mendez, and L.-É. Trudeau, “Glutamate in dopamine neurons: synaptic versus diffuse transmission,” Brain Research Reviews, vol. 58, no. 2, pp. 290–302, 2008.
- N. Bérubé-Carrière, M. Riad, G. Dal Bo, D. Lévesque, L.-É. Trudeau, and L. Descarries, “The dual dopamine-glutamate phenotype of growing mesencephalic neurons regresses in mature rat brain,” Journal of Comparative Neurology, vol. 517, no. 6, pp. 873–891, 2009.
- J. A. Mendez, M.-J. Bourque, G. Dal Bo et al., “Developmental and target-dependent regulation of vesicular glutamate transporter expression by dopamine neurons,” Journal of Neuroscience, vol. 28, no. 25, pp. 6309–6318, 2008.
- C. S. Chan, T. S. Gertler, and D. J. Surmeier, “Calcium homeostasis, selective vulnerability and Parkinson's disease,” Trends in Neurosciences, vol. 32, no. 5, pp. 249–256, 2009.
- E. B. Margolis, H. Lock, V. D. Chefer, T. S. Shippenberg, G. O. Hjelmstad, and H. L. Fields, “κ opioids selectivity control dopaminergic neurons projecting to the prefrontal cortex,” Proceedings of the National Academy of Sciences of the United States of America, vol. 103, no. 8, pp. 2938–2942, 2006.