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BioMed Research International
Volume 2013 (2013), Article ID 748160, 10 pages
Acetylsalicylic Acid Reduces the Severity of Dextran Sodium Sulfate-Induced Colitis and Increases the Formation of Anti-Inflammatory Lipid Mediators
1Department of Gastroenterology, Hepatology and Endocrinology, Virchow-Hospital, Charité Medical School, Free and Humboldt-University of Berlin, 13353 Berlin, Germany
2Laboratory for Lipid Medicine and Technology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
3Department of Radiology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA
4Lurie Family Imaging Center, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA 02115, USA
5Lipidomix GmbH, 13125 Berlin, Germany
Received 18 June 2013; Accepted 19 July 2013
Academic Editor: Gabriella Calviello
Copyright © 2013 Thomas Köhnke et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- D. C. Baumgart and S. R. Carding, “Inflammatory bowel disease: cause and immunobiology,” The Lancet, vol. 369, no. 9573, pp. 1627–1640, 2007.
- D. C. Baumgart and W. J. Sandborn, “Inflammatory bowel disease: clinical aspects and established and evolving therapies,” The Lancet, vol. 369, no. 9573, pp. 1641–1657, 2007.
- D. K. Podolsky, “Inflammatory bowel disease,” The New England Journal of Medicine, vol. 347, no. 6, pp. 417–429, 2002.
- R. J. Xavier and D. K. Podolsky, “Unravelling the pathogenesis of inflammatory bowel disease,” Nature, vol. 448, no. 7152, pp. 427–434, 2007.
- K. Takeuchi, S. Smale, P. Premchand et al., “Prevalence and mechanism of nonsteroidal anti-inflammatory drug-induced clinical relapse in patients with inflammatory bowel disease,” Clinical Gastroenterology and Hepatology, vol. 4, no. 2, pp. 196–202, 2006.
- R. S. Bloomfeld, “Are COX-2 inhibiotrs safe for anyone,” Inflammatory Bowel Diseases, vol. 12, no. 9, pp. 922–923, 2006.
- Y. El Miedany, S. Youssef, I. Ahmed, and M. El Gaafary, “The gastrointestinal safety and effect on disease activity of etoricoxib, a selective Cox-2 inhibitor in inflammatory bowel diseases,” The American Journal of Gastroenterology, vol. 101, no. 2, pp. 311–317, 2006.
- R. Matuk, J. Crawford, M. T. Abreu, S. R. Targan, E. A. Vasiliauskas, and K. A. Papadakis, “The spectrum of gastrointestinal toxicity and effect on disease activity of selective cyclooxygenase-2 inhibitors in patients with inflammatory bowel disease,” Inflammatory Bowel Diseases, vol. 10, no. 4, pp. 352–356, 2004.
- L. A. Feagins and B. L. Cryer, “Do non-steroidal anti-inflammatory drugs cause exacerbations of inflammatory bowel disease?” Digestive Diseases and Sciences, vol. 55, no. 2, pp. 226–232, 2010.
- M. Okayama, S. Hayashi, Y. Aoi, H. Nishio, S. Kato, and K. Takeuchi, “Aggravation by selective COX-1 and COX-2 inhibitors of dextran sulfate sodium (DSS)-induced colon lesions in rats,” Digestive Diseases and Sciences, vol. 52, no. 9, pp. 2095–2103, 2007.
- R. Tsubouchi, S. Hayashi, Y. Aoi et al., “Healing impairment effect of cyclooxygenase inhibitors on dextran sulfate sodium-induced colitis in rats,” Digestion, vol. 74, no. 2, pp. 91–100, 2007.
- O. Morteau, S. G. Morham, R. Sellon et al., “Impaired mucosal defense to acute colonic injury in mice lacking cyclooxygenase-1 or cyclooxygenase-2,” Journal of Clinical Investigation, vol. 105, no. 4, pp. 469–478, 2000.
- J. L. Wallace, C. M. Keenan, D. Gale, and T. S. Shoupe, “Exacerbation of experimental colitis by nonsteroidal anti-inflammatory drugs is not related to elevated leukotriene B4 synthesis,” Gastroenterology, vol. 102, no. 1, pp. 18–27, 1992.
- A. R. Martín, I. Villegas, and C. Alarcón de la Lastra, “The COX-2 inhibitor, rofecoxib, ameliorates dextran sulphate sodium induced colitis in mice,” Inflammation Research, vol. 54, no. 4, pp. 145–151, 2005.
- E. Kankuri, K. Vaali, R. Korpela, I. Paakkari, H. Vapaatalo, and E. Moilanen, “Effects of a COX-2 preferential agent nimesulide on TNBS-induced acute inflammation in the gut,” Inflammation, vol. 25, no. 5, pp. 301–310, 2001.
- K. H. Weylandt, J. X. Kang, B. Wiedenmann, and D. C. Baumgart, “Lipoxins and resolvins in inflammatory bowel disease,” Inflammatory Bowel Diseases, vol. 13, no. 6, pp. 797–799, 2007.
- C. N. Serhan, M. Hamberg, and B. Samuelsson, “Lipoxins: novel series of biologically active compounds formed from arachidonic acid in human leukocytes,” Proceedings of the National Academy of Sciences of the United States of America, vol. 81, no. 17 I, pp. 5335–5339, 1984.
- J. F. Parkinson, “Lipoxin and synthetic lipoxin analogs: an overview of anti-inflammatory functions and new concepts in immunomodulation,” Inflammation and Allergy, vol. 5, no. 2, pp. 91–106, 2006.
- A. T. Gewirtz, L. S. Collier-Hyams, A. N. Young et al., “Lipoxin A4 analogs attenuate induction of intestinal epithelial proinflammatory gene expression and reduce the severity of dextran sodium sulfate-induced colitis,” Journal of Immunology, vol. 168, no. 10, pp. 5260–5267, 2002.
- S. Fiorucci, J. L. Wallace, A. Mencarelli et al., “A β-oxidation-resistant lipoxin A4 analog treats hapten-induced colitis by attenuating inflammation and immune dysfunction,” Proceedings of the National Academy of Sciences of the United States of America, vol. 101, no. 44, pp. 15736–15741, 2004.
- C. A. Hudert, K. H. Weylandt, Y. Lu et al., “Transgenic mice rich in endogenous omega-3 fatty acids are protected from colitis,” Proceedings of the National Academy of Sciences of the United States of America, vol. 103, no. 30, pp. 11276–11281, 2006.
- M. Arita, M. Yoshida, S. Hong et al., “Resolvin E1, an endogenous lipid mediator derived from omega-3 eicosapentaenoic acid, protects against 2,4,6-trinitrobenzene sulfonic acid-induced colitis,” Proceedings of the National Academy of Sciences of the United States of America, vol. 102, no. 21, pp. 7671–7676, 2005.
- A. F. Bento, R. F. Claudino, R. C. Dutra, R. Marcon, and J. B. Calixto, “Omega-3 fatty acid-derived mediators 17(R)-hydroxy docosahexaenoic acid, aspirin-triggered resolvin D1 and resolvin D2 prevent experimental colitis in mice,” Journal of Immunology, vol. 187, no. 4, pp. 1957–1969, 2011.
- T. Ishida, M. Yoshida, M. Arita et al., “Resolvin E1, an endogenous lipid mediator derived from eicosapentaenoic acid, prevents dextran sulfate sodium-induced colitis,” Inflammatory Bowel Diseases, vol. 16, no. 1, pp. 87–95, 2010.
- S. Melgar, L. Karlsson, E. Rehnström et al., “Validation of murine dextran sulfate sodium-induced colitis using four therapeutic agents for human inflammatory bowel disease,” International Immunopharmacology, vol. 8, no. 6, pp. 836–844, 2008.
- S. Wirtz, C. Neufert, B. Weigmann, and M. F. Neurath, “Chemically induced mouse models of intestinal inflammation,” Nature Protocols, vol. 2, no. 3, pp. 541–546, 2007.
- M. F. Fredin, L. Hultin, G. Hyberg et al., “Predicting and monitoring colitis development in mice by micro-computed tomography,” Inflammatory Bowel Diseases, vol. 14, no. 4, pp. 491–499, 2008.
- A. E. Larsson, S. Melgar, E. Rehnstrom et al., “Magnetic resonance imaging of experimental mouse colitis and association with inflammatory activity,” Inflammatory Bowel Diseases, vol. 12, no. 6, pp. 478–485, 2006.
- S. Melgar, P. G. Gillberg, P. D. Hockings, and L. E. Olsson, “High-throughput magnetic resonance imaging in murine colonic inflammation,” Biochemical and Biophysical Research Communications, vol. 355, no. 4, pp. 1102–1107, 2007.
- L. A. Dieleman, M. J. Palmen, H. Akol et al., “Chronic experimental colitis induced by dextran sulphate sodium (DSS) is characterized by Th1 and Th2 cytokines,” Clinical and Experimental Immunology, vol. 114, no. 3, pp. 385–391, 1998.
- B. Gomolka, E. Siegert, K. Blossey, W.-H. Schunck, M. Rothe, and K. H. Weylandt, “Analysis of omega-3 and omega-6 fatty acid-derived lipid metabolite formation in human and mouse blood samples,” Prostaglandins and other Lipid Mediators, vol. 94, no. 3-4, pp. 81–87, 2011.
- M. Spite and C. N. Serhan, “Novel lipid mediators promote resolution of acute inflammation: impact of aspirin and statins,” Circulation Research, vol. 107, no. 10, pp. 1170–1184, 2010.
- J. Li, A. Scherl, F. Medina et al., “Impaired phagocytosis in caveolin-1 deficient macrophages,” Cell Cycle, vol. 4, no. 11, pp. 1599–1607, 2005.
- C. P. Wan, C. S. Park, and B. H. S. Lau, “A rapid and simple microfluorometric phagocytosis assay,” Journal of Immunological Methods, vol. 162, no. 1, pp. 1–7, 1993.
- P. Munkholm, “Review article: the incidence and prevalence of colorectal cancer in inflammatory bowel disease,” Alimentary Pharmacology and Therapeutics, Supplement, vol. 18, supplement 2, pp. 1–5, 2003.
- M. W. Lutgens, B. Oldenburg, P. D. Siersema et al., “Colonoscopic surveillance improves survival after colorectal cancer diagnosis in inflammatory bowel disease,” British Journal of Cancer, vol. 101, no. 10, pp. 1671–1675, 2009.
- A. T. Chan, E. L. Giovannucci, J. A. Meyerhardt, E. S. Schernhammer, G. C. Curhan, and C. S. Fuchs, “Long-term use of aspirin and nonsteroidal anti-inflammatory drugs and risk of colorectal cancer,” Journal of the American Medical Association, vol. 294, no. 8, pp. 914–923, 2005.
- L. Rosenberg, C. Louik, and S. Shapiro, “Nonsteroidal antiinflammatory drug use and reduced risk of large bowel carcinoma,” Cancer, vol. 82, no. 12, pp. 2326–2333, 1998.
- E. Flossmann and P. M. Rothwell, “Effect of aspirin on long-term risk of colorectal cancer: consistent evidence from randomised and observational studies,” The Lancet, vol. 369, no. 9573, pp. 1603–1613, 2007.
- P. M. Rothwell, M. Wilson, C.-E. Elwin et al., “Long-term effect of aspirin on colorectal cancer incidence and mortality: 20-year follow-up of five randomised trials,” The Lancet, vol. 376, no. 9754, pp. 1741–1750, 2010.
- F. S. Velayos, E. V. Loftus Jr., T. Jess et al., “Predictive and protective factors associated with colorectal cancer in ulcerative colitis: a case-control study,” Gastroenterology, vol. 130, no. 7, pp. 1941–1949, 2006.
- L. A. Stark, K. Reid, O. J. Sansom et al., “Aspirin activates the NF-κB signalling pathway and induces apoptosis in intestinal neoplasia in two in vivo models of human colorectal cancer,” Carcinogenesis, vol. 28, no. 5, pp. 968–976, 2007.
- X. Zhang, Z. Wang, Y. Zhang, Q. Jia, L. Wu, and W. Zhang, “Impact of acetylsalicylic acid on tumor angiogenesis and lymphangiogenesis through inhibition of VEGF signaling in a murine sarcoma model,” Oncology Reports, vol. 29, no. 5, pp. 1907–1913, 2013.
- M. A. Mcilhatton, J. Tyler, L. A. Kerepesi et al., “Aspirin and low-dose nitric oxide-donating aspirin increase life span in a Lynch syndrome mouse model,” Cancer Prevention Research, vol. 4, no. 5, pp. 684–693, 2011.
- N. N. Mahmoud, A. J. Dannenberg, J. Mestre et al., “Aspirin prevents tumors in a murine model of familial adenomatous polyposis,” Surgery, vol. 124, no. 2, pp. 225–231, 1998.
- Y. Tian, Y. Ye, W. Gao et al., “Aspirin promotes apoptosis in a murine model of colorectal cancer by mechanisms involving downregulation of IL-6-STAT3 signaling pathway,” International Journal of Colorectal Disease, vol. 26, no. 1, pp. 13–22, 2011.
- H. L. Newmark, “Nutrient density: an important and useful tool for laboratory animal studies,” Carcinogenesis, vol. 8, no. 7, pp. 871–873, 1987.
- A. González-Périz, A. Planagumà, K. Gronert et al., “Docosahexaenoic acid (DHA) blunts liver injury by conversion to protective lipid mediators: protectin D1 and 17S-hydroxy-DHA,” The FASEB Journal, vol. 20, no. 14, pp. 2537–2539, 2006.
- M. Spite, L. V. Norling, L. Summers et al., “Resolvin D2 is a potent regulator of leukocytes and controls microbial sepsis,” Nature, vol. 461, no. 7268, pp. 1287–1291, 2009.
- M. Spite, L. Summers, T. F. Porter, S. Srivastava, A. Bhatnagar, and C. N. Serhan, “Resolvin D1 controls inflammation initiated by glutathione-lipid conjugates formed during oxidative stress,” British Journal of Pharmacology, vol. 158, no. 4, pp. 1062–1073, 2009.
- Y.-P. Sun, S. F. Oh, J. Uddin et al., “Resolvin D1 and its aspirin-triggered 17R epimer: stereochemical assignments, anti-inflammatory properties, and enzymatic inactivation,” Journal of Biological Chemistry, vol. 282, no. 13, pp. 9323–9334, 2007.
- J. F. Lima-Garcia, R. C. Dutra, K. A. B. S. Da Silva, E. M. Motta, M. M. Campos, and J. B. Calixto, “The precursor of resolvin D series and aspirin-triggered resolvin D1 display anti-hyperalgesic properties in adjuvant-induced arthritis in rats,” British Journal of Pharmacology, vol. 164, no. 2, pp. 278–293, 2011.
- K. H. Weylandt, L. F. Krause, B. Gomolka et al., “Suppressed liver tumorigenesis in fat-1 mice with elevated omega-3 fatty acids is associated with increased omega-3 derived lipid mediators and reduced TNF-α,” Carcinogenesis, vol. 32, no. 6, pp. 897–903, 2011.
- C. Godson, S. Mitchell, K. Harvey, N. A. Petasis, N. Hogg, and H. R. Brady, “Cutting edge: lipoxins rapidly stimulate nonphlogistic phagocytosis of apoptotic neutrophils by monocyte-derived macrophages,” Journal of Immunology, vol. 164, no. 4, pp. 1663–1667, 2000.
- D. Prescott and D. M. McKay, “Aspirin-triggered lipoxin enhances macrophage phagocytosis of bacteria while inhibiting inflammatory cytokine production,” International Journal of Colorectal Disease, vol. 2301, no. 3, pp. G487–G497, 2011.
- S. Krishnamoorthy, A. Recchiuti, N. Chiang et al., “Resolvin D1 binds human phagocytes with evidence for proresolving receptors,” Proceedings of the National Academy of Sciences of the United States of America, vol. 107, no. 4, pp. 1660–1665, 2010.