Solid Lipid Nanoparticles of Guggul Lipid as Drug Carrier for Transdermal Drug Delivery

Table 2

Physical characterization of SLN and corresponding gels.

Lipid	Formulation Code	Size^*# (nm)	PDI*	ζ potential* (mV)	Entrapment efficiency* (%)	Viscosity^† (Cps)
GMS	GMN-1	101.2±3.2	0.35±0.043	−29±2.36	47.24±3.94	18560±23.4
	GMN-2	111.5±3.9	0.34±0.056	−27±3.15	56.62±2.41	18753±21.2
	GMN-3	124.2±4.1	0.31±0.028	−23±3.54	69.96±3.61	18350±20.7
SA	SAN-1	116.3±4.3	0.48±0.064	−45±4.32	39.12±4.72	16234±19.3
	SAN-2	128.9±5.1	0.45±0.055	−40±3.97	48.37±3.21	16587±24.8
	SAN-3	137.6±6.23	0.40±0.048	−36±4.15	59.32±3.59	16628±21.5
Guggul Lipid	GLN-1	98.12±1.2	0.22±0.028	−11±1.32	65.12±1.32	18123±12.1
	GLN-2	109.5±1.5	0.21±0.039	−13±1.23	76.43±1.71	18312±14.5
	GLN-3	117±1.7	0.2±0.011	−15±1.43	89.54±1.43	19401±11.8

∗Determinations performed on SLN.
^†Viscosity determined on corresponding carbopol gels.
^#Size after extrusion.
All data expressed as mean ± S.D.; 𝑛=3. 𝑃≤0.05.