Research Article
Solid Lipid Nanoparticles of Guggul Lipid as Drug Carrier for Transdermal Drug Delivery
Table 4
Permeation parameters of the CEG, CG and Different SLN formulations.
| | Formulation code | Flux
(μg/cm2/h) | Lag time
(h) | Permeation coefficient
(cm/h × 10−3) | Distribution coefficient
(cm2/h × 10−3) | Enhancement ratio |
| | CG | 0.317 | 2.8 | 0.0317 | 1.25 | 1 | | CEG | 1.074 | 2.3 | 0.0925 | 1.56 | 2.917 | | GMNG-1 | 2.661 | 1.675 | 0.532 | 2.089 | 16.78 | | GMNG-2 | 3.43 | 1.475 | 0.686 | 2.372 | 21.64 | | GMNG-3 | 3.94 | 1.17 | 0.788 | 2.991 | 24.85 | | SANG-1 | 1.63 | 1.9 | 0.326 | 1.842 | 10.28 | | SANG-2 | 2.03 | 1.5 | 0.406 | 2.333 | 12.8 | | SANG-3 | 2.529 | 1.3 | 0.505 | 2.692 | 15.93 | | GLNG-1 | 4.128 | 1.1 | 0.825 | 3.1 | 26.02 | | GLNG-2 | 4.591 | 1.05 | 0.918 | 3.3 | 28.95 | | GLNG-3 | 6.363 | 0.4 | 1.25 | 8.7 | 39.43 |
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CG: Carbopol gel (Conataing 1% Diclofenac Sodium).
CEG: Comercial Emulgel.
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