Increasing Affinity of Interferon-𝜸 Receptor 1 to Interferon-𝜸 by Computer-Aided Design

Figure 1

The interface between IFN-𝛾 and the extracellular part of its receptor 1 (IFN-𝛾-Rx) from crystal structure 1fg9 [17]. Two IFN-𝛾-Rx molecules are drawn as blue cartoon and IFN-𝛾 homodimer as green cartoon. The receptor residues forming the interface with IFN-𝛾 are drawn as yellow sticks, the residues selected for mutations are highlighted in red, and the residue N96 in magenta. All the selected mutations are listed in Table 2.