Promoter Hypermethylation of the EMP3 Gene in a Series of 229 Human Gliomas
Figure 3
EMP3 immunohistochemistry in astrocytic and oligodendroglial tumors. (a) GBM (unmethylated EMP3 promoter) with EMP3 cytoplasmic-cell membrane expression; DAB, 200x. (b) id in one WHO grade III oligodendroglioma (unmethylated EMP3 promoter); DAB, 400x. (c) WHO grade II oligoastrocytoma (methylated EMP3 promoter) with EMP3 positive perivascular infiltrates; DAB, 200x. (d) WHO grade II oligodendroglioma (methylated EMP3 promoter) with EMP3 positive perivascular cuffing of lymphocytes; DAB, 200x. (e) WHO grade II oligodendroglioma (methylated EMP3 promoter) with EMP3 positive macrophages; DAB, 400x. (f) id with PAS-positive macrophages, 400x.