757126.fig.003a
(a) Normal cellular architecture
757126.fig.003b
(b) Microvesicular accumulation of fats
757126.fig.003c
(c) Accumulation of mononuclear cells (1). Presence of Ito cells (2)
757126.fig.003d
(d) Lower intensity of mononuclear accumulations (1). Single cells showing intracellular oedema (2)
757126.fig.003e
(e) Low-grade oedema of the cells
Figure 3: Histopathological profile. (a) Liver tissue from control rats revealed normal cellular architecture (magnification 400x). (b) Liver tissue from paracetamol-treated group revealed a presence of centriacinar and microvesicular accumulation of fats (magnification 400x). (c) Liver tissue from paracetamol-treated group revealed accumulation of mononuclear cells and reaction of the connective tissue around the bile ducts. Hyperplasia of cholangiocytes and presence of Ito (magnification 400x). (d) Liver tissue from rats pretreated with saponarin and then challenged with paracetamol showing lower intensity of mononuclear accumulations and the presence of single cells showing intracellular oedema (magnification 400x). (e) Liver tissue from rats pretreated with silymarin and then challenged with paracetamol low-grade oedema of the cells (magnification 400x).