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BioMed Research International
Volume 2013 (2013), Article ID 757126, 10 pages
http://dx.doi.org/10.1155/2013/757126
Research Article

Hepatoprotective and Antioxidant Effects of Saponarin, Isolated from Gypsophila trichotoma Wend. on Paracetamol-Induced Liver Damage in Rats

1Laboratory of Drug Metabolism and Drug Toxicity, Department of Pharmacology, Pharmacotherapy and Toxicology, Faculty of Pharmacy, Medical University, 2 Dunav Street, 1000 Sofia, Bulgaria
2CFSAN, US FDA, 5100 Paint Branch, Parkway College Park, MD 20740, USA
3Department of Pharmacognosy, Faculty of Pharmacy, Medical University, 2 Dunav Street, 1000 Sofia, Bulgaria
4Department of Obstetrics, Gynecology, Biotechnology of Reproduction, Pathological Anatomy and Biochemistry, Faculty of Veterinary Medicine, University of Forestry, 10 Kliment Ohridski Boulevard, 1756 Sofia, Bulgaria

Received 20 April 2013; Revised 4 June 2013; Accepted 4 June 2013

Academic Editor: Bernd Schnabl

Copyright © 2013 Rumyana Simeonova et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

HPLC chromatogram of saponarin: HPLC was performed on Shimadzu 10 Advp (Japan) chromatographic system (UV-VIS detector SPD with fixed analytical wavelengths set at 254 nm); Spherisorb C18 ODS column 5 µm, 250 x 4.6 mm; mobile phases: MeOH-H2O (70:30 v/v); flow-rate: 1.5 mL/min-1.

  1. Supplementary Material