Hepatoprotective and Antioxidant Effects of Saponarin, Isolated from Gypsophila trichotoma Wend. on Paracetamol-Induced Liver Damage in Rats
Table 1
Effect of saponarin (SP) and silymarin (SL) on cell viability, LDH leakage into the medium, GSH level, and MDA quantity assessed in isolated rat hepatocytes.
Group
Viability (%)
LDH (μmol/min/mill cells)
GSH (nmol/mill cells)
MDA (nmol/mill cells)
Control
83 ± 3.4
0.112 ± 0.03
22 ± 1.9
0.07 ± 0.01
SP 60 μg/mL
53 ± 3.8*
0.204 ± 0.05*
12 ± 0.5*
0.123 ± 0.01*
SP 6 μg/mL
67 ± 3.8*
0.173 ± 0.04*
15 ± 0.5*
0.09 ± 0.002*
SP 0.06 μg/mL
76 ± 1.5
0.166 ± 0.07*
20 ± 2.2
0.08 ± 0.01
SP 0.006 μg/mL
77 ± 2.5
0.142 ± 0.04*
21 ± 1.1
0.07 ± 0.01
SL 50 μg/mL
44 ± 1.6*
0.210 ± 0.01*
10 ± 0.5*
0.136 ± 0.003*
SL 5 μg/mL
61 ± 1.1*
0.159 ± 0.03*
15 ± 1.1*
0.127 ± 0.002*
SL 0.05 μg/mL
69 ± 1.5*
0.140 ± 0.06*
17 ± 1.6
0.09 ± 0.003*
SL 0.005 μg/mL
79 ± 5.5
0.115 ± 0.04
18 ± 4.4
0.08 ± 0.002*
Data are expressed as mean ± SEM of four different experiments. *Significant difference from control values (Mann-Whitney U test, ).
