Table 1: Effect of saponarin (SP) and silymarin (SL) on cell viability, LDH leakage into the medium, GSH level, and MDA quantity assessed in isolated rat hepatocytes.

Group Viability (%)LDH (μmol/min/mill cells)GSH (nmol/mill cells)MDA (nmol/mill cells)

Control83 ± 3.40.112 ± 0.0322 ± 1.90.07 ± 0.01
SP 60 μg/mL 53 ± 3.8*0.204 ± 0.05*12 ± 0.5*0.123 ± 0.01*
SP 6 μg/mL 67 ± 3.8*0.173 ± 0.04*15 ± 0.5*0.09 ± 0.002*
SP 0.06 μg/mL 76 ± 1.50.166 ± 0.07*20 ± 2.20.08 ± 0.01
SP 0.006 μg/mL 77 ± 2.50.142 ± 0.04*21 ± 1.10.07 ± 0.01
SL 50 μg/mL 44 ± 1.6*0.210 ± 0.01*10 ± 0.5*0.136 ± 0.003*
SL 5 μg/mL 61 ± 1.1*0.159 ± 0.03*15 ± 1.1*0.127 ± 0.002*
SL 0.05 μg/mL 69 ± 1.5*0.140 ± 0.06*17 ± 1.60.09 ± 0.003*
SL 0.005 μg/mL 79 ± 5.50.115 ± 0.0418 ± 4.40.08 ± 0.002*

Data are expressed as mean ± SEM of four different experiments. *Significant difference from control values (Mann-Whitney U test, ).