|Table 2: Effect of saponarin and silymarin pretreatment on hepatic liver peroxidation and antioxidant profile in rats challenged with paracetamol.|
|Treatment: paracetamol administered at a dose of 600 mg/kg i.p., alone (PC group) and two hours after the last administration of the hepatoprotective agents (SP + PC and SL + PC groups); saponarin (SP) (80 mg/kg bw/day) and silymarin (SL) (100 mg/kg bw/day were administered p.o. for 7 days. Data are expressed as mean ± SEM of six rats. *Significant difference from control values (Mann-Whitney U test, ). +Significant difference from paracetamol-treated group (Mann- Whitney U test, ).|
cμmol H2O2/min/mg protein.
dnmol CDNB-GSH conjugate formed/min/mg protein.