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BioMed Research International
Volume 2013 (2013), Article ID 761617, 6 pages
http://dx.doi.org/10.1155/2013/761617
Research Article

Plasma miR-126 Is a Potential Biomarker for Early Prediction of Type 2 Diabetes Mellitus in Susceptible Individuals

1Department of Laboratory Medicine, Shenzhen Nanshan Center for Chronic Disease Control, Shenzhen, Guangdong 518054, China
2Department of Control and Prevention for Chronic Non-Communicable Diseases, Shenzhen Nanshan Center for Chronic Disease Control, Shenzhen, Guangdong 518054, China
3Biomedical Research Institute, Shenzhen PKU-HKUST Medical Center, Shenzhen, Guangdong 518036, China
4Shenzhen Key Laboratory for Translational Medicine of Dermatology, Shenzhen PKU-HKUST Medical Center, Shenzhen, Guangdong 518036, China
5Shenzhen Key Discipline of Dermatology, Peking University Shenzhen Hospital, Shenzhen, Guangdong 518036, China
6Department of Social and Preventive Medicine, School of Public Health and Health Professions, The State University of New York, Buffalo, NY 14214, USA
7Department of Cancer Genetics, Roswell Park Cancer Institute, Buffalo, NY 14263, USA

Received 14 September 2013; Accepted 14 December 2013

Academic Editor: Thean Hock Tang

Copyright © 2013 Tao Zhang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Type 2 diabetes mellitus (T2DM) is a major public health problem in China. Diagnostic markers are urgently needed to identify individuals at risk of developing T2DM and encourage them to adapt to a healthier life style. Circulating miRNAs present important sources of noninvasive biomarkers of various diseases. Recently, a novel plasma microRNA signature was identified in T2DM. Here, we evaluated the T2DM-related miRNA signature in plasma of three study groups: normal (fasting glucose (FG), 4.8–5.2 mmol/L), T2DM-susceptible (FG, 6.1–6.9 mmol/L), and T2DM individuals (FG, ≥7.0 mmol/L) and tested the feasibility of using circulating miRNAs to identify individuals at risk of developing T2DM. Among the 5 miRNAs included in the signature, miR-29b and miR-28-3p are not detectable. miR-15a and miR-223 have comparable expression levels among three groups. Notably, miR-126 is the only miRNA that showed significantly reduced expression in susceptible individuals and T2DM patients compared to normal individuals, suggesting that miR-126 in circulation may serve as a potential biomarker for early identification of susceptible individuals to T2DM.