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BioMed Research International
Volume 2013 (2013), Article ID 763096, 11 pages
http://dx.doi.org/10.1155/2013/763096
Clinical Study

Measurement of the Silver Ion Concentration in Wound Fluids after Implantation of Silver-Coated Megaprostheses: Correlation with the Clinical Outcome

1Trauma Surgery Department, University Hospital Essen, Hufelandstraße 55, 45122 Essen, Germany
2Orthopaedic Department, University of Duisburg-Essen, Hufelandstraße 55, 45122 Essen, Germany

Received 1 April 2013; Accepted 15 May 2013

Academic Editor: Kurt G. Naber

Copyright © 2013 B. Hussmann et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. J. Hardes, C. Gebert, A. Schwappach, et al., “Characteristics and outcome of infections associated with tumor endoprostheses,” Archives of Orthopaedic and Trauma Surgery, vol. 126, pp. 289–296, 2006.
  2. F. Mittermayer, P. Krepler, M. Dominkus et al., “Long-term followup of uncemented tumor endoprostheses for the lower extremity,” Clinical Orthopaedics and Related Research, vol. 388, pp. 167–177, 2001. View at Scopus
  3. J. Hardes, H. Ahrens, C. Gebert et al., “Lack of toxicological side-effects in silver-coated megaprostheses in humans,” Biomaterials, vol. 28, no. 18, pp. 2869–2875, 2007. View at Publisher · View at Google Scholar · View at Scopus
  4. H. Ahrens, G. Gosheger, A. Streitbürger, C. Gebert, and J. Hardes, “Antimikrobielle Silberbeschichtung von Tumorprothesen,” Der Onkologe, vol. 12, pp. 145–151, 2006. View at Publisher · View at Google Scholar
  5. H. J. Park, J. Y. Kim, J. Kim et al., “Silver-ion-mediated reactive oxygen species generation affecting bactericidal activity,” Water Research, vol. 43, no. 4, pp. 1027–1032, 2009. View at Publisher · View at Google Scholar · View at Scopus
  6. J. S. Kim, E. Kuk, K. N. Yu et al., “Antimicrobial effects of silver nanoparticles,” Nanomedicine, vol. 3, no. 1, pp. 95–101, 2007. View at Publisher · View at Google Scholar · View at Scopus
  7. S. A. Jones, P. G. Bowler, M. Walker, and D. Parsons, “Controlling wound bioburden with a novel silver-containing Hydrofiber dressing,” Wound Repair and Regeneration, vol. 12, no. 3, pp. 288–294, 2004. View at Publisher · View at Google Scholar · View at Scopus
  8. O. Gordon, T. V. Slenters, P. S. Brunetto et al., “Silver coordination polymers for prevention of implant infection: thiol interaction, impact on respiratory chain enzymes, and hydroxyl radical induction,” Antimicrobial Agents and Chemotherapy, vol. 54, no. 10, pp. 4208–4218, 2010. View at Publisher · View at Google Scholar · View at Scopus
  9. G. Gosheger, J. Hardes, H. Ahrens et al., “Silver-coated megaendoprostheses in a rabbit model—an analysis of the infection rate and toxicological side effects,” Biomaterials, vol. 25, no. 24, pp. 5547–5556, 2004. View at Publisher · View at Google Scholar · View at Scopus
  10. J. Hardes, C. von Eiff, A. Streitbuerger et al., “Reduction of periprosthetic infection with silver-coated megaprostheses in patients with bone sarcoma,” Journal of Surgical Oncology, vol. 101, no. 5, pp. 389–395, 2010. View at Publisher · View at Google Scholar · View at Scopus
  11. W. Jung, H. C. Koo, K. W. Kim, S. Shin, S. H. Kim, and Y. H. Park, “Antibacterial activity and mechanism of action of the silver ion in Staphylococcus aureus and Escherichia coli,” Applied and Environmental Microbiology, vol. 74, no. 7, pp. 2171–2178, 2008. View at Publisher · View at Google Scholar · View at Scopus
  12. R. Rahil-Khazen, B. J. Bolann, A. Myking, and R. J. Ulvik, “Multi-element analysis of trace element levels in human autopsy tissues by using inductively coupled atomic emission spectrometry technique (ICP-AES),” Journal of Trace Elements in Medicine and Biology, vol. 16, no. 1, pp. 15–25, 2002. View at Scopus
  13. G. P. Castelli, C. Pognani, M. Meisner, A. Stuani, D. Bellomi, and L. Sgarbi, “Procalcitonin and C-reactive protein during systemic inflammatory response syndrome, sepsis and organ dysfunction,” Critical Care, vol. 8, no. 4, pp. R234–R242, 2004. View at Scopus
  14. C. von Eiff, G. Peters, and C. Heilmann, “Pathogenesis of infections due to coagulase-negative staphylococci,” The Lancet Infectious Diseases, vol. 2, no. 11, pp. 677–685, 2002. View at Publisher · View at Google Scholar · View at Scopus
  15. E. Sheehan, J. McKenna, K. J. Mulhall, P. Marks, and D. McCormack, “Adhesion of Staphylococcus to orthopaedic metals, an in vivo study,” Journal of Orthopaedic Research, vol. 22, no. 1, pp. 39–43, 2004. View at Publisher · View at Google Scholar · View at Scopus
  16. A. M. Straub, J. Suvan, N. P. Lang et al., “Phase 1 evaluation of a local delivery device releasing silver ions in periodontal pockets: safety, pharmacokinetics and bioavailability,” Journal of Periodontal Research, vol. 36, no. 3, pp. 187–193, 2001. View at Scopus
  17. G. Zhao and S. E. Stevens Jr., “Multiple parameters for the comprehensive evaluation of the susceptibility of Escherichia coli to the silver ion,” BioMetals, vol. 11, no. 1, pp. 27–32, 1998. View at Publisher · View at Google Scholar · View at Scopus
  18. N. Shahabadi, M. Maghsudi, and Z. Ahmadipour, “Study on the interaction of silver(I) complex with bovine serum albumin by spectroscopic techniques,” Spectrochimica Acta A, vol. 92, pp. 184–188, 2012.
  19. J. M. Schierholz, L. J. Lucas, A. Rump, and G. Pulverer, “Efficacy of silver-coated medical devices,” Journal of Hospital Infection, vol. 40, no. 4, pp. 257–262, 1998. View at Scopus
  20. G. A. Fielding, M. Roy, A. Bandyopadhyay, and S. Bose, “Antibacterial and biological characteristics of silver containing and strontium doped plasma sprayed hydroxyapatite coatings,” Acta Biomaterialia, vol. 8, pp. 3144–3315, 2012. View at Publisher · View at Google Scholar
  21. C. E. Albers, W. Hofstetter, K. A. Siebenrock, R. Landmann, and F. M. Klenke, “In vitro cytotoxicity of silver nanoparticles on osteoblasts and osteoclasts at antibacterial concentrations,” Nanotoxicology, vol. 7, no. 1, pp. 30–36, 2013. View at Publisher · View at Google Scholar
  22. H. Rosengren and A. Dixon, “Antibacterial prophylaxis in dermatologic surgery: an evidence-based review,” American Journal of Clinical Dermatology, vol. 11, no. 1, pp. 35–44, 2010. View at Publisher · View at Google Scholar · View at Scopus
  23. X. Wu, J. Li, L. Wang, D. Huang, Y. Zuo, and Y. Li, “The release properties of silver ions from Ag-nHA/TiO2/PA66 antimicrobial composite scaffolds,” Biomedical Materials, vol. 5, no. 4, Article ID 044105, 2010. View at Publisher · View at Google Scholar · View at Scopus
  24. K. D. Rosenman, A. Moss, and S. Kon, “Argyria: clinical implications of exposure to silver nitrate and silver oxide,” Journal of Occupational Medicine, vol. 21, no. 6, pp. 430–435, 1979. View at Scopus
  25. A. Brutel de la Riviere, K. M. E. Dossche, D. E. Birnbaum, and R. Hacker, “First clinical experience with a mechanical valve with silver coating,” Journal of Heart Valve Disease, vol. 9, no. 1, pp. 123–130, 2000. View at Scopus
  26. K. S. Tweden, J. D. Cameron, A. J. Razzouk, W. R. Holmberg, and S. J. Kelly, “Biocompatibility of silver-modified polyester for antimicrobial protection of prosthetic valves,” Journal of Heart Valve Disease, vol. 6, no. 5, pp. 553–561, 1997. View at Scopus
  27. G. Perrelli and G. Piolatto, “Tentative reference values for gold, silver and platinum: literature data analysis,” Science of the Total Environment, vol. 120, no. 1-2, pp. 93–96, 1992. View at Publisher · View at Google Scholar · View at Scopus
  28. E. Sudmann, H. Vik, M. Rait et al., “Systemic and local silver accumulation after total hip replacement using silver-impregnated bone cement,” Medical Progress through Technology, vol. 20, no. 3-4, pp. 179–184, 1994. View at Scopus
  29. J. M. White, A. M. Powell, K. Brady, and R. Russell-Jones, “Severe generalized argyria secondary to ingestion ofcolloidal silver protein,” Clinical and Experimental Dermatology, vol. 28, pp. 254–256, 2003. View at Publisher · View at Google Scholar
  30. A. T. Wan, R. A. J. Conyers, C. J. Coombs, and J. P. Masterton, “Determination of silver in blood, urine, and tissues of volunteers and burn patients,” Clinical Chemistry, vol. 37, no. 10, pp. 1683–1687, 1991. View at Scopus
  31. S. D. Adams, B. A. Cotton, M. F. McGuire, et al., “Unique pattern of complications in elderly trauma patients at a Level I trauma center,” The Journal of Trauma and Acute Care Surgery, vol. 72, pp. 112–118, 2012. View at Publisher · View at Google Scholar
  32. S. J. Ham, H. S. Koops, R. P. H. Veth, J. R. van Horn, W. M. Molenaar, and H. J. Hoekstra, “Limb salvage surgery for primary bone sarcoma of the lower extremities: long-term consequences of endoprosthetic reconstructions,” Annals of Surgical Oncology, vol. 5, no. 5, pp. 423–436, 1998. View at Publisher · View at Google Scholar · View at Scopus
  33. P. Ritschl, R. Capanna, U. Helwig, M. Campanacci, and R. Kotz, “KMFTR modular prosthesis system for the lower extremity: kotz modular femur tibia reconstruction system,” Zeitschrift fur Orthopadie und Ihre Grenzgebiete, vol. 130, no. 4, pp. 290–293, 1992. View at Scopus
  34. P. Z. Wirganowicz, J. J. Eckardt, F. J. Dorey, F. R. Eilber, and J. M. Kabo, “Etiology and results of tumor endoprosthesis revision surgery in 64 patients,” Clinical Orthopaedics and Related Research, vol. 358, pp. 64–74, 1999. View at Scopus
  35. A. Hillmann, G. Gosheger, C. Hoffmann, T. Ozaki, and W. Winkelmann, “Rotationplasty—surgical treatment modality after failed limb salvage procedure,” Archives of Orthopaedic and Trauma Surgery, vol. 120, no. 10, pp. 555–558, 2000. View at Scopus
  36. L. Y. Shih, F. H. Sim, D. J. Pritchard, M. G. Rock, and E. Y. S. Chao, “Segmental total knee arthroplasty after distal femoral resection for tumor,” Clinical Orthopaedics and Related Research, vol. 292, pp. 269–281, 1993. View at Scopus
  37. C. von Eiff, R. A. Proctor, and G. Peters, “Coagulase-negative staphylococci: pathogens have major role in nosocomial infections,” Postgraduate Medicine, vol. 110, no. 4, pp. 63–76, 2001. View at Scopus
  38. M. Herrmann and G. Peters, Catheter-Associated Infections Caused By Coagulase-Negative Staphylococci: Clinical and Biological Aspects, Marcel Dekke, New York, NY, USA, 1997.