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BioMed Research International
Volume 2013 (2013), Article ID 783490, 9 pages
http://dx.doi.org/10.1155/2013/783490
Research Article

Anthelmintic Effects of Alkylated Diamines and Amino Alcohols against Schistosoma mansoni

1Departamento de Química, Universidade Federal de Juiz de Fora, 36036-330 Juiz de Fora, MG, Brazil
2Departamento de Bioquímica e Imunologia, Universidade de São Paulo, 14049-900 Ribeirão Preto, SP, Brazil
3Departamento de Ciências Farmacêuticas, Faculdade de Farmácia, Universidade Federal de Juiz de Fora, 36036-900 Juiz de Fora, MG, Brazil

Received 27 April 2013; Accepted 8 July 2013

Academic Editor: Graciela Russomando

Copyright © 2013 Fábio de Souza Fernandes et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Polyamines are substances involved in many aspects of cell growth, division, and differentiation. Because of the metabolic differences between host cells and parasite cells, polyamine metabolism has been considered as a potential target for the chemotherapy of parasitic diseases. The aim of this work was to evaluate the schistosomicidal activity of different N-alkylated diamines (3a3h), amino alcohols (4a4d), and glycosylated amino alcohols (10a10d). Compounds were prepared by synthetic methods and submitted to in vitro evaluation against adult worms of Schistosoma mansoni. At 100  M, 3b, 3e, and 3h as well as 4a, 4b, 4d, 10a, 10b, and 10d resulted in 100% mortality of adult schistosomes. Compound 3d (12.5 to 100  M) caused the death of 100% of both male and female adult schistosomes, while 3f (12.5 to 100  M) resulted in 100% mortality of only male adult worms, whereas no mortality in female worms was observed. Compounds 3d and 3f were also able to reduce viability and decrease production of developed eggs in comparison with the negative control group. Diamines 3d and 3f may represent useful lead compounds for further optimization in order to develop new schistosomicidal agents.