Table 1: Effective concentration, EC50 (μM) of lasalocid, silybin, and lasalocid EC50 in the interaction with silybin 1–250 μM range concentrations estimated by the MTT, CBB, and LDH assays on chicken hepatoma (LMH) and rat myoblasts (L6) cell line, mean ± SEM, ( ).

LasalocidSilybinSilybin with lasalocid (~EC50)
LMHL6LMHL6LMHL6

MTT7.0 ± 0.54a14.0 ± 1.08b70.4 ± 1.05 a247 ± 3.90 c114 ± 11.37 aN/D
CBB6.8 ± 0.55 a20.9 ± 1.36c93.4 ± 2.63 b104 ± 6.50d154 ± 9.22 bN/D
LDH8.1 ± 0.54 a7.6 ± 1.39 a93.6 ± 0.98 b70.5 ± 9.51 a157 ± 6.65 b42.7 ± 1.15 c

The different superscripts (a, b, c, d) within a column of compounds indicate significant differences between the methods ( ), N/D: not detected within the studied concentration range.