Review Article
Cell Transplantation for Spinal Cord Injury: A Systematic Review
Table 3
In vivo transplantations of neural stem/progenitor cells.
| | First author | Year | SCI Models | Main graft | Transplantation methods | Pre-differentiation or pretreated | Combination | Tissue sparing | Neuronal regeneration | Axonal regeneration
/remyelination | Sensory function | Motor function | Cavity and/or scare formation | Inflammation | Others |
| Åkesson,
[79] | 2007 | T8, clamp compression-rats | human spinal cord-derived neurospheres | Lesion epicenter i. medu. | — | — | — | Imp. | — | — | — | — | — | — | | Webber, [80] | 2007 | C4, dorsal hemisection-rats | Fetal NSCs-rats | Lesion site,
rostral and caudal
i. medu. | — | — | — | No Imp. | No Imp. | Partially Imp. | No Imp. | — | — | High glial differentiation rate | | Tarasenko, [81] | 2007 | T9-10, contusion-rats | Human fetal NSCs | Lesion epicenter i. medu. | — | — | — | Imp. | Imp. | — | Imp. | — | — | — | | Yan, [82] | 2007 | L4 and L5 roots avulsion—nude rats | Human fetal NSCs | Lesion epicenter i. medu. | — | — | — | Imp. | Imp. | — | — | — | — | Synaptic contact reformation | | Yasuda, [83] | 2011 | T10, contusion-mice | Mouse fetal NSCs | Lesion epicenter i. medu. | — | — | Imp. | Imp. | Imp. | — | Imp. | — | — | — | | Hwang, [84] | 2009 | T9-10, contusion-rats | Human fetal NSCs | Lesion epicenter and rostral
i. medu. | Olig2-transfection | — | Imp. | Imp. | Imp. | Imp. | Imp. | Imp. | — | — | | Alexanian, [85] | 2010 | T8, compressed-rats | Human fetal NPs | Rostral and caudal
i. medu. | Differentiated to OPCs | — | — | — | Imp. | Imp. | Imp. | — | — | — | | Wang, [86] | 2010 | 3/4 lateral transection-rats | Rats fetal NSCs | Rostral and caudal
i. medu. | — | NSCs + OECs | — | Imp. | Imp. | — | Imp. | — | — | — | | Salazar, [87] | 2010 | T9, contusion-mice | Human fetal NSCs | Rostral and caudal
i. medu. | — | — | No Imp. | Imp. | — | No Imp. | Imp. | No Imp. | — | — |
|
|
—: Not reported; Imp.: Improvement; i. medu.: intramedullary injection; SCI: spinal cord injury; NSCs: neural stem cells; NPs: neural precursors; OPCs: oligodendrocyte progenitor cells; OECs: olfactory ensheathing cells.
|
