Review Article
Cell Transplantation for Spinal Cord Injury: A Systematic Review
Table 5
In vivo transplantations of Schwann cells.
| | First author | Year | SCI Models | Main graft | Transplantation methods | Pre-differentiation or pretreated | Combination | Tissue sparing | Neuronal regeneration | Axonal regeneration
/remyelination | Sensory function | Motor function | Cavity and/or scare formation | Inflammation | Others |
| | Biernaskie, [107] | 2007 | T10, contusion-rats | Rats SKP-SCs | Lesion epicenter i. medu. | — | — | Imp. | Imp. | Imp. | — | Imp. | Imp. | — | — | | Agudo, [108] | 2008 | C4, dorsal hemisection-rats | SCPs-postnatal 2d rats | Rostral and caudal
i. medu. | — | — | — | — | Imp. | No Imp. | No Imp. | Imp. | — | Enhanced angiogenesis | | Patel, [109] | 2010 | T9, contusion-rats | Rats SCs | Lesion epicenter i. medu. | — | Gelling matrix (laminin + collagen) + SCs | — | — | Imp. | — | Imp. | — | — | — | | Olson, [110] | 2009 | T8-9, transection-rats | Rats SCs | Lesion epicenter i. medu. | — | Gelling matrix + NSCs + SCs | — | Imp. | Imp. | — | No Imp. | — | — | — | | Ban, [68] | 2011 | T9, contusion-rats | Rats SCs | Lesion epicenter i. medu. | — | MSCs + SCs | — | — | Imp. | — | Imp. | Imp. | — | — | | Fouad, [111] | 2005 | T8, complete removal of a 4-mm length of spinal cord-rats | Rats SCs | Lesion site,
rostral and caudal i. medu. | — | Gelling matrix + MSCs + SCs | — | — | Imp. | Imp. | Imp. | — | — | — | | Sharp, [112] | 2012 | T9, contusion-rats | Rats SCs | Lesion site,
i. medu. | — | SCs + dbCAMP | — | — | Imp. | — | No Imp. | — | — | — |
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—: Not reported; Imp.: Improvement; i. medu.: intramedullary injection; SCI: spinal cord injury; SCs: Schwann cells; SKP: skin-derived precursors; SCPs: Schwann cell precursors; dbCAMP, dibutyryl CAMP; MSCs: mesenchymal stem cells.
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