The Effect of Apigenin on Pharmacokinetics of Imatinib and Its Metabolite N-Desmethyl Imatinib in Rats
Figure 2
HPLC chromatograms of imatinib and N-desmethyl imatinib. (a) Representative chromatograms of blank serum. (b) Representative chromatograms of imatinib (5 μg/mL) and N-desmethyl imatinib (0.5 μg/mL). (c) Representative chromatograms of the serum spiked with imatinib (2.5 μg/mL) and N-desmethyl imatinib (0.25 μg/mL). (d) Representative chromatograms of the serum obtained at 3 h after a single oral dose of 30 mg/kg imatinib. A: N-desmethyl imatinib, B: imatinib, and C: phenacetin.
