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BioMed Research International
Volume 2013 (2013), Article ID 792940, 9 pages
http://dx.doi.org/10.1155/2013/792940
Research Article

Rikkunshito, a Japanese Kampo Medicine, Ameliorates Decreased Feeding Behavior via Ghrelin and Serotonin 2B Receptor Signaling in a Novelty Stress Murine Model

1Tsumura Research Laboratories, Tsumura & Co., Ibaraki 300-1192, Japan
2Pathophysiology and Therapeutics, Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Hokkaido 060-0812, Japan
3Department of Gastroenterology and Hepatology, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido 060-8638, Japan
4Department of Medical Gastroenterology, National Hospital Organization Hokkaido Medical Center, Sapporo, Hokkaido 063-0005, Japan

Received 28 June 2013; Revised 21 August 2013; Accepted 29 August 2013

Academic Editor: Mahmood Ameen Abdulla

Copyright © 2013 Chihiro Yamada et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [12 citations]

The following is the list of published articles that have cited the current article.

  • Hironobu Tsubouchi, Shigehisa Yanagi, Ayako Miura, Sachiko Mogami, Chihiro Yamada, Seiichi Iizuka, Tomohisa Hattori, and Masamitsu Nakazato, “Rikkunshito ameliorates cachexia associated with bleomycin-induced lung fibrosis in mice by stimulating ghrelin secretion,” Nutrition Research, 2014. View at Publisher · View at Google Scholar
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  • Lixin Wang, Sachiko Mogami, Seiichi Yakabi, Hiroshi Karasawa, Chihiro Yamada, Koji Yakabi, Tomohisa Hattori, and Yvette Tache, “Patterns of Brain Activation and Meal Reduction Induced by Abdominal Surgery in Mice and Modulation by Rikkunshito,” Plos One, vol. 10, no. 9, 2015. View at Publisher · View at Google Scholar
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  • Yayoi Saegusa, Tomohisa Hattori, Miwa Nahata, Chihiro Yamada, and Hiroshi Takeda, “A New Strategy Using Rikkunshito to Treat Anorexia and Gastrointestinal Dysfunction,” Evidence-Based Complementary and Alternative Medicine, vol. 2015, pp. 1–10, 2015. View at Publisher · View at Google Scholar
  • Wayne E. Pratt, Kara A. Clissold, Peagan Lin, Amanda E. Cain, Alexa F. Ciesinski, Thomas R. Hopkins, Adeolu O. Ilesanmi, Erin A. Kelly, Zachary Pierce-Messick, Daniel S. Powell, and Ian A. Rosner, “A systematic investigation of the differential roles for ventral tegmentum serotonin 1- and 2-type receptors on food intake in the rat,” Brain Research, 2016. View at Publisher · View at Google Scholar
  • Sachiko Mogami, Chiharu Sadakane, Miwa Nahata, Yasuharu Mizuhara, Chihiro Yamada, Tomohisa Hattori, and Hiroshi Takeda, “CRF receptor 1 antagonism and brain distribution of active components contribute to the ameliorative effect of rikkunshito on stress-induced anorexia,” Scientific Reports, vol. 6, pp. 27516, 2016. View at Publisher · View at Google Scholar
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  • Anjana Bali, and Amteshwar Singh Jaggi, “An Integrative Review on Role and Mechanisms of Ghrelin in Stress, Anxiety and Depression,” Current Drug Targets, vol. 17, no. 5, pp. 495–507, 2016. View at Publisher · View at Google Scholar