About this Journal Submit a Manuscript Table of Contents
BioMed Research International
Volume 2013 (2013), Article ID 792940, 9 pages
http://dx.doi.org/10.1155/2013/792940
Research Article

Rikkunshito, a Japanese Kampo Medicine, Ameliorates Decreased Feeding Behavior via Ghrelin and Serotonin 2B Receptor Signaling in a Novelty Stress Murine Model

1Tsumura Research Laboratories, Tsumura & Co., Ibaraki 300-1192, Japan
2Pathophysiology and Therapeutics, Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Hokkaido 060-0812, Japan
3Department of Gastroenterology and Hepatology, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido 060-8638, Japan
4Department of Medical Gastroenterology, National Hospital Organization Hokkaido Medical Center, Sapporo, Hokkaido 063-0005, Japan

Received 28 June 2013; Revised 21 August 2013; Accepted 29 August 2013

Academic Editor: Mahmood Ameen Abdulla

Copyright © 2013 Chihiro Yamada et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. C. Ó. Luanaigh and B. A. Lawlor, “Loneliness and the health of older people,” International Journal of Geriatric Psychiatry, vol. 23, no. 12, pp. 1213–1221, 2008. View at Publisher · View at Google Scholar · View at Scopus
  2. A. Steptoe, N. Owen, S. R. Kunz-Ebrecht, and L. Brydon, “Loneliness and neuroendocrine, cardiovascular, and inflammatory stress responses in middle-aged men and women,” Psychoneuroendocrinology, vol. 29, no. 5, pp. 593–611, 2004. View at Publisher · View at Google Scholar · View at Scopus
  3. V. Bhatia and R. K. Tandon, “Stress and the gastrointestinal tract,” Journal of Gastroenterology and Hepatology, vol. 20, no. 3, pp. 332–339, 2005. View at Publisher · View at Google Scholar · View at Scopus
  4. C. Lo Sauro, C. Ravaldi, P. L. Cabras, C. Faravelli, and V. Ricca, “Stress, hypothalamic-pituitary-adrenal axis and eating disorders,” Neuropsychobiology, vol. 57, no. 3, pp. 95–115, 2008. View at Publisher · View at Google Scholar · View at Scopus
  5. R. J. Handa, M. K. Cross, M. George et al., “Neuroendocrine and neurochemical responses to novelty stress in young and old male F344 rats: effects of d-fenfluramine treatment,” Pharmacology Biochemistry and Behavior, vol. 46, no. 1, pp. 101–109, 1993. View at Scopus
  6. H. Miura, H. Qiao, and T. Ohta, “Influence of aging and social isolation on changes in brain monoamine turnover and biosynthesis of rats elicited by novelty stress,” Synapse, vol. 46, no. 2, pp. 116–124, 2002. View at Publisher · View at Google Scholar · View at Scopus
  7. A. J. Bechtholt, T. E. Hill, and I. Lucki, “Anxiolytic effect of serotonin depletion in the novelty-induced hypophagia test,” Psychopharmacology, vol. 190, no. 4, pp. 531–540, 2007. View at Publisher · View at Google Scholar · View at Scopus
  8. J. C. G. Halford, J. A. Harrold, E. J. Boyland, C. L. Lawton, and J. E. Blundell, “Serotonergic drugs: effects on appetite expression and use for the treatment of obesity,” Drugs, vol. 67, no. 1, pp. 27–55, 2007. View at Publisher · View at Google Scholar · View at Scopus
  9. L. H. Tecott, “Serotonin and the orchestration of energy balance,” Cell Metabolism, vol. 6, no. 5, pp. 352–361, 2007. View at Publisher · View at Google Scholar · View at Scopus
  10. L. K. Heisler, N. Pronchuk, K. Nonogaki et al., “Serotonin activates the hypothalamic-pituitary-adrenal axis via serotonin 2C receptor stimulation,” Journal of Neuroscience, vol. 27, no. 26, pp. 6956–6964, 2007. View at Publisher · View at Google Scholar · View at Scopus
  11. J. De Vry and R. Schreiber, “Effects of selected serotonin 5-HT1 and 5-HT2 receptor agonists on feeding behavior: possible mechanisms of action,” Neuroscience and Biobehavioral Reviews, vol. 24, no. 3, pp. 341–353, 2000. View at Publisher · View at Google Scholar · View at Scopus
  12. T. Hattori, K. Yakabi, and H. Takeda, “Cisplatin-induced anorexia and ghrelin,” Vitamins & Hormones, vol. 92, pp. 301–317, 2013.
  13. H. Takeda, C. Sadakane, T. Hattori et al., “Rikkunshito, an herbal medicine, suppresses cisplatin-induced anorexia in rats via 5-HT2 receptor antagonism,” Gastroenterology, vol. 134, no. 7, pp. 2004–2013, 2008. View at Publisher · View at Google Scholar · View at Scopus
  14. Y. Saegusa, H. Takeda, S. Muto et al., “Decreased plasma ghrelin contributes to anorexia following novelty stress,” American Journal of Physiology: Endocrinology and Metabolism, vol. 301, no. 4, pp. E685–E696, 2011. View at Publisher · View at Google Scholar · View at Scopus
  15. M. Kojima, H. Hosoda, Y. Date, M. Nakazato, H. Matsuo, and K. Kangawa, “Ghrelin is a growth-hormone-releasing acylated peptide from stomach,” Nature, vol. 402, no. 6762, pp. 656–660, 1999. View at Publisher · View at Google Scholar · View at Scopus
  16. Y. Date, N. Murakami, K. Toshinai et al., “The role of the gastric afferent vagal nerve in Ghrelin-induced feeding and growth hormone secretion in rats,” Gastroenterology, vol. 123, no. 4, pp. 1120–1128, 2002. View at Publisher · View at Google Scholar · View at Scopus
  17. M. Nakazato, N. Murakami, Y. Date et al., “A role for ghrelin in the central regulation of feeding,” Nature, vol. 409, no. 6817, pp. 194–198, 2001. View at Publisher · View at Google Scholar · View at Scopus
  18. N. Fujitsuka, A. Asakawa, Y. Uezono et al., “Potentiation of ghrelin signaling attenuates cancer anorexia-cachexia and prolongs survival,” Translational Psychiatry, vol. 1, article e23, 2011. View at Publisher · View at Google Scholar · View at Scopus
  19. N. Fujitsuka, A. Asakawa, M. Hayashi et al., “Selective serotonin reuptake inhibitors modify physiological gastrointestinal motor activities via 5-HT2c receptor and acyl ghrelin,” Biological Psychiatry, vol. 65, no. 9, pp. 748–759, 2009. View at Publisher · View at Google Scholar · View at Scopus
  20. D. W. Bonhaus, C. Bach, A. DeSouza et al., “The pharmacology and distribution of human 5-hydroxytryptamine2B (5-HT2B) receptor gene products: comparison with 5-HT2A and 5-HT2C receptors,” British Journal of Pharmacology, vol. 115, no. 4, pp. 622–628, 1995. View at Scopus
  21. R. H. P. Porter, K. R. Benwell, H. Lamb et al., “Functional characterization of agonists at recombinant human 5-HT2A, 5-HT2B and 5-HT2C receptors in CHO-K1 cells,” British Journal of Pharmacology, vol. 128, no. 1, pp. 13–20, 1999. View at Publisher · View at Google Scholar · View at Scopus
  22. L. Prut and C. Belzung, “The open field as a paradigm to measure the effects of drugs on anxiety-like behaviors: a review,” European Journal of Pharmacology, vol. 463, no. 1-3, pp. 3–33, 2003. View at Publisher · View at Google Scholar · View at Scopus
  23. S. C. Dulawa and R. Hen, “Recent advances in animal models of chronic antidepressant effects: the novelty-induced hypophagia test,” Neuroscience and Biobehavioral Reviews, vol. 29, no. 4-5, pp. 771–783, 2005. View at Publisher · View at Google Scholar · View at Scopus
  24. M. Nahata, S. Muto, K. Nakagawa et al., “Serotonin 2C receptor antagonism ameliorates novelty-induced hypophagia in aged mice,” Psychoneuroendocrinology, vol. 38, no. 10, pp. 2051–2064, 2013. View at Publisher · View at Google Scholar
  25. M. Tschop, D. L. Smiley, and M. L. Heiman, “Ghrelin induces adiposity in rodents,” Nature, vol. 407, no. 6806, pp. 908–913, 2000. View at Publisher · View at Google Scholar · View at Scopus
  26. T. Matsumura, M. Arai, Y. Yonemitsu et al., “The traditional Japanese medicine Rikkunshito increases the plasma level of ghrelin in humans and mice,” Journal of Gastroenterology, vol. 45, no. 3, pp. 300–307, 2010. View at Publisher · View at Google Scholar · View at Scopus
  27. C. Sadakane, S. Muto, K. Nakagawa et al., “10-Gingerol, a component of rikkunshito, improves cisplatin-induced anorexia by inhibiting acylated ghrelin degradation,” Biochemical and Biophysical Research Communications, vol. 412, no. 3, pp. 506–511, 2011. View at Publisher · View at Google Scholar · View at Scopus
  28. M. Yanai, E. Mochiki, A. Ogawa et al., “Intragastric administration of rikkunshito stimulates upper gastrointestinal motility and gastric emptying in conscious dogs,” Journal of Gastroenterology, vol. 48, no. 5, pp. 611–619, 2013.
  29. K. Yakabi, C. Sadakane, M. Noguchi et al., “Reduced ghrelin secretion in the hypothalamus of rats due to cisplatin-induced anorexia,” Endocrinology, vol. 151, no. 8, pp. 3773–3782, 2010. View at Publisher · View at Google Scholar · View at Scopus
  30. K. Yakabi, S. Kurosawa, M. Tamai et al., “Rikkunshito and 5-HT2C receptor antagonist improve cisplatin-induced anorexia via hypothalamic ghrelin interaction,” Regulatory Peptides, vol. 161, no. 1–3, pp. 97–105, 2010. View at Publisher · View at Google Scholar · View at Scopus
  31. A. L. Auclair, A. Cathala, F. Sarrazin et al., “The central serotonin 2B receptor: a new pharmacological target to modulate the mesoaccumbens dopaminergic pathway activity,” Journal of Neurochemistry, vol. 114, no. 5, pp. 1323–1332, 2010. View at Publisher · View at Google Scholar · View at Scopus
  32. D.-S. Choi and L. Maroteaux, “Immunohistochemical localisation of the serotonin 5-HT2B receptor in mouse gut, cardiovascular system, and brain,” FEBS Letters, vol. 391, no. 1-2, pp. 45–51, 1996. View at Publisher · View at Google Scholar · View at Scopus
  33. G. S. Baxter, O. E. Murphy, and T. P. Blackburn, “Further characterization of 5-hydroxytryptamine receptors (putative 5-HT2B) in rat stomach fundus longitudinal muscle,” British Journal of Pharmacology, vol. 112, no. 1, pp. 323–331, 1994. View at Scopus
  34. S. V. Wu, P.-Q. Yuan, J. Lai et al., “Activation of type 1 CRH receptor isoforms induces serotonin release from human carcinoid BON-1N cells: an enterochromaffin cell model,” Endocrinology, vol. 152, no. 1, pp. 126–137, 2011. View at Publisher · View at Google Scholar · View at Scopus
  35. M. G. Pshennikova, E. V. Popkova, and M. V. Shimkovich, “Adaptation to stress improves resistance to gastric damage during acute stress in Wistar rats and decreases resistance in August rats: role of serotonin,” Bulletin of Experimental Biology and Medicine, vol. 134, no. 4, pp. 329–332, 2002. View at Publisher · View at Google Scholar · View at Scopus