- About this Journal ·
- Abstracting and Indexing ·
- Aims and Scope ·
- Annual Issues ·
- Article Processing Charges ·
- Author Guidelines ·
- Bibliographic Information ·
- Citations to this Journal ·
- Contact Information ·
- Editorial Board ·
- Editorial Workflow ·
- Free eTOC Alerts ·
- Publication Ethics ·
- Recently Accepted Articles ·
- Reviewers Acknowledgment ·
- Submit a Manuscript ·
- Subscription Information ·
- Table of Contents
BioMed Research International
Volume 2013 (2013), Article ID 792940, 9 pages
Rikkunshito, a Japanese Kampo Medicine, Ameliorates Decreased Feeding Behavior via Ghrelin and Serotonin 2B Receptor Signaling in a Novelty Stress Murine Model
1Tsumura Research Laboratories, Tsumura & Co., Ibaraki 300-1192, Japan
2Pathophysiology and Therapeutics, Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Hokkaido 060-0812, Japan
3Department of Gastroenterology and Hepatology, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido 060-8638, Japan
4Department of Medical Gastroenterology, National Hospital Organization Hokkaido Medical Center, Sapporo, Hokkaido 063-0005, Japan
Received 28 June 2013; Revised 21 August 2013; Accepted 29 August 2013
Academic Editor: Mahmood Ameen Abdulla
Copyright © 2013 Chihiro Yamada et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- C. Ó. Luanaigh and B. A. Lawlor, “Loneliness and the health of older people,” International Journal of Geriatric Psychiatry, vol. 23, no. 12, pp. 1213–1221, 2008.
- A. Steptoe, N. Owen, S. R. Kunz-Ebrecht, and L. Brydon, “Loneliness and neuroendocrine, cardiovascular, and inflammatory stress responses in middle-aged men and women,” Psychoneuroendocrinology, vol. 29, no. 5, pp. 593–611, 2004.
- V. Bhatia and R. K. Tandon, “Stress and the gastrointestinal tract,” Journal of Gastroenterology and Hepatology, vol. 20, no. 3, pp. 332–339, 2005.
- C. Lo Sauro, C. Ravaldi, P. L. Cabras, C. Faravelli, and V. Ricca, “Stress, hypothalamic-pituitary-adrenal axis and eating disorders,” Neuropsychobiology, vol. 57, no. 3, pp. 95–115, 2008.
- R. J. Handa, M. K. Cross, M. George et al., “Neuroendocrine and neurochemical responses to novelty stress in young and old male F344 rats: effects of d-fenfluramine treatment,” Pharmacology Biochemistry and Behavior, vol. 46, no. 1, pp. 101–109, 1993.
- H. Miura, H. Qiao, and T. Ohta, “Influence of aging and social isolation on changes in brain monoamine turnover and biosynthesis of rats elicited by novelty stress,” Synapse, vol. 46, no. 2, pp. 116–124, 2002.
- A. J. Bechtholt, T. E. Hill, and I. Lucki, “Anxiolytic effect of serotonin depletion in the novelty-induced hypophagia test,” Psychopharmacology, vol. 190, no. 4, pp. 531–540, 2007.
- J. C. G. Halford, J. A. Harrold, E. J. Boyland, C. L. Lawton, and J. E. Blundell, “Serotonergic drugs: effects on appetite expression and use for the treatment of obesity,” Drugs, vol. 67, no. 1, pp. 27–55, 2007.
- L. H. Tecott, “Serotonin and the orchestration of energy balance,” Cell Metabolism, vol. 6, no. 5, pp. 352–361, 2007.
- L. K. Heisler, N. Pronchuk, K. Nonogaki et al., “Serotonin activates the hypothalamic-pituitary-adrenal axis via serotonin 2C receptor stimulation,” Journal of Neuroscience, vol. 27, no. 26, pp. 6956–6964, 2007.
- J. De Vry and R. Schreiber, “Effects of selected serotonin 5-HT1 and 5-HT2 receptor agonists on feeding behavior: possible mechanisms of action,” Neuroscience and Biobehavioral Reviews, vol. 24, no. 3, pp. 341–353, 2000.
- T. Hattori, K. Yakabi, and H. Takeda, “Cisplatin-induced anorexia and ghrelin,” Vitamins & Hormones, vol. 92, pp. 301–317, 2013.
- H. Takeda, C. Sadakane, T. Hattori et al., “Rikkunshito, an herbal medicine, suppresses cisplatin-induced anorexia in rats via 5-HT2 receptor antagonism,” Gastroenterology, vol. 134, no. 7, pp. 2004–2013, 2008.
- Y. Saegusa, H. Takeda, S. Muto et al., “Decreased plasma ghrelin contributes to anorexia following novelty stress,” American Journal of Physiology: Endocrinology and Metabolism, vol. 301, no. 4, pp. E685–E696, 2011.
- M. Kojima, H. Hosoda, Y. Date, M. Nakazato, H. Matsuo, and K. Kangawa, “Ghrelin is a growth-hormone-releasing acylated peptide from stomach,” Nature, vol. 402, no. 6762, pp. 656–660, 1999.
- Y. Date, N. Murakami, K. Toshinai et al., “The role of the gastric afferent vagal nerve in Ghrelin-induced feeding and growth hormone secretion in rats,” Gastroenterology, vol. 123, no. 4, pp. 1120–1128, 2002.
- M. Nakazato, N. Murakami, Y. Date et al., “A role for ghrelin in the central regulation of feeding,” Nature, vol. 409, no. 6817, pp. 194–198, 2001.
- N. Fujitsuka, A. Asakawa, Y. Uezono et al., “Potentiation of ghrelin signaling attenuates cancer anorexia-cachexia and prolongs survival,” Translational Psychiatry, vol. 1, article e23, 2011.
- N. Fujitsuka, A. Asakawa, M. Hayashi et al., “Selective serotonin reuptake inhibitors modify physiological gastrointestinal motor activities via 5-H receptor and acyl ghrelin,” Biological Psychiatry, vol. 65, no. 9, pp. 748–759, 2009.
- D. W. Bonhaus, C. Bach, A. DeSouza et al., “The pharmacology and distribution of human 5-hydroxytryptamine2B (5-H) receptor gene products: comparison with 5-H and 5-H receptors,” British Journal of Pharmacology, vol. 115, no. 4, pp. 622–628, 1995.
- R. H. P. Porter, K. R. Benwell, H. Lamb et al., “Functional characterization of agonists at recombinant human 5-H, 5-H and 5-H receptors in CHO-K1 cells,” British Journal of Pharmacology, vol. 128, no. 1, pp. 13–20, 1999.
- L. Prut and C. Belzung, “The open field as a paradigm to measure the effects of drugs on anxiety-like behaviors: a review,” European Journal of Pharmacology, vol. 463, no. 1-3, pp. 3–33, 2003.
- S. C. Dulawa and R. Hen, “Recent advances in animal models of chronic antidepressant effects: the novelty-induced hypophagia test,” Neuroscience and Biobehavioral Reviews, vol. 29, no. 4-5, pp. 771–783, 2005.
- M. Nahata, S. Muto, K. Nakagawa et al., “Serotonin 2C receptor antagonism ameliorates novelty-induced hypophagia in aged mice,” Psychoneuroendocrinology, vol. 38, no. 10, pp. 2051–2064, 2013.
- M. Tschop, D. L. Smiley, and M. L. Heiman, “Ghrelin induces adiposity in rodents,” Nature, vol. 407, no. 6806, pp. 908–913, 2000.
- T. Matsumura, M. Arai, Y. Yonemitsu et al., “The traditional Japanese medicine Rikkunshito increases the plasma level of ghrelin in humans and mice,” Journal of Gastroenterology, vol. 45, no. 3, pp. 300–307, 2010.
- C. Sadakane, S. Muto, K. Nakagawa et al., “10-Gingerol, a component of rikkunshito, improves cisplatin-induced anorexia by inhibiting acylated ghrelin degradation,” Biochemical and Biophysical Research Communications, vol. 412, no. 3, pp. 506–511, 2011.
- M. Yanai, E. Mochiki, A. Ogawa et al., “Intragastric administration of rikkunshito stimulates upper gastrointestinal motility and gastric emptying in conscious dogs,” Journal of Gastroenterology, vol. 48, no. 5, pp. 611–619, 2013.
- K. Yakabi, C. Sadakane, M. Noguchi et al., “Reduced ghrelin secretion in the hypothalamus of rats due to cisplatin-induced anorexia,” Endocrinology, vol. 151, no. 8, pp. 3773–3782, 2010.
- K. Yakabi, S. Kurosawa, M. Tamai et al., “Rikkunshito and 5-H receptor antagonist improve cisplatin-induced anorexia via hypothalamic ghrelin interaction,” Regulatory Peptides, vol. 161, no. 1–3, pp. 97–105, 2010.
- A. L. Auclair, A. Cathala, F. Sarrazin et al., “The central serotonin 2B receptor: a new pharmacological target to modulate the mesoaccumbens dopaminergic pathway activity,” Journal of Neurochemistry, vol. 114, no. 5, pp. 1323–1332, 2010.
- D.-S. Choi and L. Maroteaux, “Immunohistochemical localisation of the serotonin 5-H receptor in mouse gut, cardiovascular system, and brain,” FEBS Letters, vol. 391, no. 1-2, pp. 45–51, 1996.
- G. S. Baxter, O. E. Murphy, and T. P. Blackburn, “Further characterization of 5-hydroxytryptamine receptors (putative 5-H) in rat stomach fundus longitudinal muscle,” British Journal of Pharmacology, vol. 112, no. 1, pp. 323–331, 1994.
- S. V. Wu, P.-Q. Yuan, J. Lai et al., “Activation of type 1 CRH receptor isoforms induces serotonin release from human carcinoid BON-1N cells: an enterochromaffin cell model,” Endocrinology, vol. 152, no. 1, pp. 126–137, 2011.
- M. G. Pshennikova, E. V. Popkova, and M. V. Shimkovich, “Adaptation to stress improves resistance to gastric damage during acute stress in Wistar rats and decreases resistance in August rats: role of serotonin,” Bulletin of Experimental Biology and Medicine, vol. 134, no. 4, pp. 329–332, 2002.