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BioMed Research International
Volume 2013 (2013), Article ID 794984, 6 pages
http://dx.doi.org/10.1155/2013/794984
Research Article

Reduction of Orbital Inflammation following Decompression for Thyroid-Related Orbitopathy

1Division of Oculofacial Plastic and Reconstructive Surgery, UCSD Department of Ophthalmology, CA, USA
2Thyroid Eye Center, UCSD Department of Ophthalmology, La Jolla, CA, USA
3Division of Oculofacial Plastic and Reconstructive Surgery, Department of Ophthalmology, The Permanente Medical Group, Sacramento, CA, USA
4UCSD Department of Ophthalmology, La Jolla, CA, USA
5UCSD Department of Neurosciences, La Jolla, CA, USA
6Division of Pediatric Ophthalmology, UCSD Department of Ophthalmology, CA, USA

Received 3 April 2013; Accepted 30 May 2013

Academic Editor: Anton M. Jetten

Copyright © 2013 Sang-Rog Oh et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Purpose. Thyroid-related orbitopathy (TRO) is associated with inflammation, expansion of orbital fat, enlargement of extraocular muscles, and optic neuropathy (ON). We examined the effects of orbital decompression on the inflammatory and congestive signs of TRO in patients who underwent emergent orbital decompression. Methods. This retrospective, consecutive study included patients with ON from TRO who underwent orbital decompression. Pre- and postoperative orbital inflammatory signs in the operated and nonoperated, contralateral eyes were graded with the 10-item clinical activity score (CAS). Results. Thirty-one orbits were included. Postoperatively, 22 patients and 29 orbits had resolution of ON while the remaining 2 patients had improvement in visual acuity. Mean preoperative CAS was 9.5 ± 0.4. At 12 months, postoperative CAS was 2.1 ± 0.6 ( ) in the operated eye and 3.2 ± 0.5 ( ) in the nonoperated, contralateral eye. Conclusion. In our series, 94% of orbits had resolution of ON. There was also a statistically significant postoperative reduction in the CAS in both the operated and nonoperated, contralateral eyes. This phenomenon may be due to lowered venous congestion, decreased intraorbital pressure, and diminution in inflammatory factors.