About this Journal Submit a Manuscript Table of Contents
BioMed Research International
Volume 2013 (2013), Article ID 795458, 13 pages
http://dx.doi.org/10.1155/2013/795458
Research Article

Chitosan Dermal Substitute and Chitosan Skin Substitute Contribute to Accelerated Full-Thickness Wound Healing in Irradiated Rats

1Reconstructive Sciences Unit, School of Medical Sciences, Universiti Sains Malaysia, 16150 Kelantan, Malaysia
2Craniofacial Laboratory, School of Dental Sciences, Universiti Sains Malaysia, 16150 Kelantan, Malaysia

Received 4 July 2013; Revised 12 September 2013; Accepted 29 September 2013

Academic Editor: Esmaiel Jabbari

Copyright © 2013 Abu Bakar Mohd Hilmi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. C. Sussman and B. M. Bates-Jansen, “Wound healing physiology: acute and chronic,” in Wound Care a Collaborative Practice Manual for Health Professionals, C. Sussman and B. M. Bates-Jensen, Eds., pp. 21–51, Wolters Kluwer Health/Lippincott Williams & Wilkins, Philadelphia, Pa, USA, 2007.
  2. A. D. Metcalfe and M. W. J. Ferguson, “Tissue engineering of replacement skin: the crossroads of biomaterials, wound healing, embryonic development, stem cells and regeneration,” Journal of the Royal Society Interface, vol. 4, no. 14, pp. 413–437, 2007. View at Publisher · View at Google Scholar · View at Scopus
  3. E. S. Gil, B. Panilaitis, E. Bellas, and D. L. Kaplan, “Functionalized silk biomaterials for wound healing,” Advanced Healthcare Materials, vol. 2, pp. 206–217, 2013.
  4. P. Kaspler, M. Pintilie, and R. P. Hill, “Dynamics of micronuclei in rat skin fibroblasts after X irradiation,” Radiation Research, vol. 172, no. 1, pp. 106–113, 2009. View at Publisher · View at Google Scholar · View at Scopus
  5. M. A. Biel, T. Kim, and M. J. Trump, “Effect of radiation therapy and Photofrin on tissue response in a rat model,” Lasers in Surgery and Medicine, vol. 13, no. 6, pp. 672–676, 1993. View at Publisher · View at Google Scholar · View at Scopus
  6. M. Hilmi, A. Bakar, A. S. Halim et al., “In vitro characterization of a chitosan skin regenerating template as a scaffold for cells cultivation,” SpringerPlus, vol. 2, no. 1, p. 79, 2013.
  7. A. B. M. Hilmi, A. S. Halim, N. M. Noor, et al., “A simple culture method for epithelial stem cells derived from human hair follicle,” Central European Journal of Biology, vol. 8, pp. 432–439, 2013.
  8. O. Ziv-Polat, M. Topaz, T. Brosh, and S. Margel, “Enhancement of incisional wound healing by thrombin conjugated iron oxide nanoparticles,” Biomaterials, vol. 31, no. 4, pp. 741–747, 2010. View at Publisher · View at Google Scholar · View at Scopus
  9. T. Nishiyama, I. Kii, T. G. Kashima et al., “Delayed re-epithelialization in periostin-deficient mice during cutaneous wound healing,” PLoS ONE, vol. 6, no. 4, Article ID e18410, 2011. View at Publisher · View at Google Scholar · View at Scopus
  10. X. Liang, S. Bhattacharya, G. Bajaj et al., “Delayed cutaneous wound healing and aberrant expression of hair follicle stem cell markers in mice selectively lacking ctip2 in epidermis,” PLoS ONE, vol. 7, no. 2, Article ID e29999, 2012. View at Publisher · View at Google Scholar · View at Scopus
  11. J. L. Burns, J. S. Mancoll, and L. G. Phillips, “Impairments to wound healing,” Clinics in Plastic Surgery, vol. 30, no. 1, pp. 47–56, 2003. View at Publisher · View at Google Scholar · View at Scopus
  12. M. Ito, Y. Liu, Z. Yang et al., “Stem cells in the hair follicle bulge contribute to wound repair but not to homeostasis of the epidermis,” Nature Medicine, vol. 11, pp. 1351–1354, 2005. View at Scopus
  13. R. A. Bryant and D. P. Nix, Acute and Chronic Wounds: Current Management Concepts, Elsevier Mosby, Edinburgh, UK, 2007.
  14. C. Sussman, “Assessment of the skin and wound,” in Wound Care a Collaborative Practice Manual for Health Professionals, C. Sussman and B. M. Bates-Jensen, Eds., pp. 85–122, Wolters Kluwer Health/Lippincott Williams & Wilkins, Philadelphia, Pa, USA, 3rd edition, 2007.
  15. R. A. F. Clark, “Cutaneous tissue repair: basic biologic considerations. I,” Journal of the American Academy of Dermatology, vol. 13, no. 5, pp. 701–725, 1985. View at Scopus
  16. C. R. Flach, G. Zhang, and R. Mendelsohn, “Raman microscopy and imaging: applications to skin pharmacology and wound healing,” in Emerging Raman Applications and Techniques in Biomedical and Pharmaceutical Fields, P. Matousek and M. D. Morris, Eds., pp. 365–384, Springer, Heidelberg, Germany, 2010.
  17. C. B. Croft and D. Tarin, “Ultrastructural studies of wound healing in mouse skin. I. Epithelial behaviour,” Journal of Anatomy, vol. 106, no. 1, pp. 63–77, 1970. View at Scopus
  18. S. Holloway, K. Harding, J. K. Stechmiller, and G. Schultz, “Acute and chronic wound healing,” in Wound Care Essentials: Practice Principles, S. Baranoski and E. A. Ayello, Eds., pp. 83–100, Lippincott Williams & Wilkins, Philadelphia, Pa, USA, 3rd edition, 2012.
  19. W. B. Rockwell, I. K. Cohen, and H. P. Ehrlich, “Keloids and hypertrophic scars: a comprehensive review,” Plastic and Reconstructive Surgery, vol. 84, no. 5, pp. 827–837, 1989. View at Scopus
  20. G. C. Gurtner, S. Werner, Y. Barrandon, and M. T. Longaker, “Wound repair and regeneration,” Nature, vol. 453, no. 7193, pp. 314–321, 2008. View at Publisher · View at Google Scholar · View at Scopus
  21. NPUAP, “Support surface standard initiative. Terms and definitation related to support surfaces,” National Pressure Ulcer Advisory Panel, 2007.
  22. M. Kempf, Y. Miyamura, P. Y. Liu et al., “A denatured collagen microfiber scaffold seeded with human fibroblasts and keratinocytes for skin grafting,” Biomaterials, vol. 32, no. 21, pp. 4782–4792, 2011. View at Publisher · View at Google Scholar · View at Scopus
  23. W. A. Dorsett-Martin, “Rat models of skin wound healing: a review,” Wound Repair and Regeneration, vol. 12, no. 6, pp. 591–599, 2004. View at Publisher · View at Google Scholar · View at Scopus
  24. S. J. M. Yussof, A. S. Halim, A. Z. M. Saad, and H. Jaafar, “Evaluation of the biocompatibility of a bilayer chitosan skin regenerating template, human skin allograft, and integra implants in rats,” ISRN Materials Science, vol. 2011, Article ID 857483, 7 pages, 2011. View at Publisher · View at Google Scholar
  25. F. Haubner, E. Ohmann, F. Pohl, J. Strutz, and H. G. Gassner, “Wound healing after radiation therapy: review of the literature,” Radiation Oncology, vol. 7, p. 162, 2012.
  26. F. Schwenter, B. L. Schneider, W. F. Pralong, N. Déglon, and P. Aebischer, “Survival of encapsulated human primary fibroblasts and erythropoietin expression under xenogeneic conditions,” Human Gene Therapy, vol. 15, no. 7, pp. 669–680, 2004. View at Publisher · View at Google Scholar · View at Scopus
  27. A. Stoff, A. A. Rivera, N. S. Banerjee et al., “Promotion of incisional wound repair by human mesenchymal stem cell transplantation,” Experimental Dermatology, vol. 18, no. 4, pp. 362–369, 2009. View at Publisher · View at Google Scholar · View at Scopus
  28. R. Periyasamy and M. Rathinasamy, “Nonimmunogenecity of human amniotic epithelial cells in circulation and subcutaneous tissue of the wistar albino rats,” International Journal of Basic and Applied Medical Sciences, vol. 3, no. 1, pp. 267–275, 2013.
  29. A. de Mendonça Costa, D. F. Bueno, M. T. Martins et al., “Reconstruction of large cranial defects in nonimmunosuppressed experimental design with human dental pulp stem cells,” Journal of Craniofacial Surgery, vol. 19, no. 1, pp. 204–210, 2008. View at Publisher · View at Google Scholar · View at Scopus
  30. V. C. Sandulache, Z. Zhou, A. Sherman, J. E. Dohar, and P. A. Hebda, “Impact of transplanted fibroblasts on rabbit skin wounds,” Archives of Otolaryngology, vol. 129, no. 3, pp. 345–350, 2003. View at Scopus
  31. H. Ohyama, F. Nishimura, M. Meguro, S. Takashiba, Y. Murayama, and S. Matsushita, “Counter-antigen presentation: fibroblasts produce cytokines by signalling through HLA class II molecules without inducing T-cell proliferation,” Cytokine, vol. 17, no. 4, pp. 175–181, 2002. View at Publisher · View at Google Scholar · View at Scopus
  32. A. Bartholomew, C. Sturgeon, M. Siatskas et al., “Mesenchymal stem cells suppress lymphocyte proliferation in vitro and prolong skin graft survival in vivo,” Experimental Hematology, vol. 30, no. 1, pp. 42–48, 2002. View at Publisher · View at Google Scholar · View at Scopus
  33. M. D. Nicola, C. Carlo-Stella, M. Magni et al., “Human bone marrow stromal cells suppress T-lymphocyte proliferation induced by cellular or nonspecific mitogenic stimuli,” Blood, vol. 99, no. 10, pp. 3838–3843, 2002. View at Publisher · View at Google Scholar · View at Scopus
  34. W. T. Tse, J. D. Pendleton, W. M. Beyer, M. C. Egalka, and E. C. Guinan, “Suppression of allogeneic T-cell proliferation by human marrow stromal cells: implications in transplantation,” Transplantation, vol. 75, no. 3, pp. 389–397, 2003. View at Publisher · View at Google Scholar · View at Scopus
  35. T. Yi and S. Su, “Immunomodulatory properties of mesenchymal stem cells and their therapeutic applications,” Archives of Pharmacal Research, vol. 35, pp. 213–221, 2012.
  36. E. Mansilla, G. H. Marin, F. Sturla et al., “Human mesenchymal stem cells are tolerized by mice and improve skin and spinal cord injuries,” Transplantation Proceedings, vol. 37, no. 1, pp. 292–294, 2005. View at Publisher · View at Google Scholar · View at Scopus
  37. A. J. Nauta and W. E. Fibbe, “Immunomodulatory properties of mesenchymal stromal cells,” Blood, vol. 110, no. 10, pp. 3499–3506, 2007. View at Publisher · View at Google Scholar · View at Scopus