MHC Universal Cells Survive in an Allogeneic Environment after Incompatible Transplantation

Table 1

Cytokine secretion profile.

Analytes pg/mL	LEW (RT1-A cells)	LEW (RT1-A-silenced cells)	LEW.1W (RT1-A cells)	LEW.1W (RT1-A-silenced cells)
IL-1α	17.0 ± 5.9	15.5 ± 5.0	80.7 ± 20.3∗∗∗	22.7 ± 10.3
IL-1β	23.2 ± 10.4	27.8 ± 9.2	130.9 ± 80.3∗∗∗	32.1 ± 6.4
IL-6	8.0 ± 1.5	8.3 ± 2.1	45.9 ± 18.2∗∗∗	10.3 ± 5.2
TNF-α	7.0 ± 3.2	7.2 ± 3.7	678.3 ± 345.4∗∗∗	36.2 ± 29.8
IFN-γ	138.9 ± 58.7	126.2 ± 73.4	789.6 ± 111.2∗∗∗	159.8 ± 123.6

Levels of different cytokines were measured in sera of LEW and LEW.1W rats transplanted with RT1-A-expressing fibroblasts (RT1-A cells) or RT1-A-silenced fibroblasts. Statistically significant differences are indicated by asterisks (***𝑃<0.001).