Genetic Epidemiology, Hematological and Clinical Features of Hemoglobinopathies in Iran

Table 1

Common types of hemoglobinopathies in various parts of Iran.

Area	𝛼-Chain variants	𝛽-Chain variants	𝛼-Thalassemia	𝛽-Thalassemia
Northern Iran
Gilan			−α ^3.7 kb (42.5%)	IVS II-1 G : A (52.4%)
Mazandaran			−α ^3.7 kb (44.9%)	IVS II-1 G : A (62.1%)
Golestan				IVS II-1 G : A (33.3%)
Northwestern Iran
East Azerbaijan and Ardabil				IVS II-1 G : A (21%)
West Azerbaijan				IVS II-1 G : A (35%)
Northeastern Iran
Khorasan				CD 8/9 +G (62.5%)
Central Iran
Isfahan		Hb S		IVS II-1 G : A (20.5 and 28%)
Southwestern Iran
Fars		Hb S	α ^3.7 kb (71.7%)	IVS II-1 G : A (24, 31 and 47.8%)
Khuzestan		Hb S; Hb D-Punjab	−α ^3.7 kb (62.6%)	CD 36/37 –T (20.5%); IVS II-1 G : A (20%)
Western Iran
Kermanshah	Hb Q-Iran; Hb Setif	Hb D-Punjab		IVS II-1 G : A (33%)
Kurdistan				IVS II-1 G : A (35%)
Lorestan				CD 36/37 –T (33.8%); IVS II-1 G : A (27.7%)
Southern Iran
Hormozgan			−α ^3.7 kb (79.1%)	IVS I-5 G : C (69%)
Southeastern Iran
Sistan-Balouchestan				IVS I-5 G : C (87.2%)
Kerman			−α ^3.7 kb (83.8%)	IVS I-5 G : C (66.2%)
Iranians (with different ethnicity)			−α ^3.7 kb (60.2%)	IVS II-1 G : A (34%)