- About this Journal ·
- Abstracting and Indexing ·
- Aims and Scope ·
- Annual Issues ·
- Article Processing Charges ·
- Articles in Press ·
- Author Guidelines ·
- Bibliographic Information ·
- Citations to this Journal ·
- Contact Information ·
- Editorial Board ·
- Editorial Workflow ·
- Free eTOC Alerts ·
- Publication Ethics ·
- Reviewers Acknowledgment ·
- Submit a Manuscript ·
- Subscription Information ·
- Table of Contents
BioMed Research International
Volume 2013 (2013), Article ID 805627, 12 pages
Role of M2 Muscarinic Receptor in the Airway Response to Methacholine of Mice Selected for Minimal or Maximal Acute Inflammatory Response
1Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, 05508-000 São Paulo, Brazil
2Cell Signaling and Nanobiotechnology Laboratory, Department of Biochemistry and Immunology, Federal University of Minas Gerais, Minas Gerais, 31270-901 Belo Horizonte, Brazil
3Laboratory of Imunogenetics, Instituto Butantan, 05503-900 São Paulo, Brazil
4Department of Pharmacology, Institute of Biomedical Sciences, University of São Paulo, 05508-900 São Paulo, Brazil
Received 3 December 2012; Revised 16 February 2013; Accepted 18 February 2013
Academic Editor: Alexandre de Paula Rogerio
Copyright © 2013 Juciane Maria de Andrade Castro et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- A. D. Fryer and D. B. Jacoby, “Muscarinic receptors and control of airway smooth muscle,” American Journal of Respiratory and Critical Care Medicine, vol. 158, no. 5, pp. S154–S160, 1998.
- A. F. Roffel, C. R. Elzinga, and J. Zaagsma, “Muscarinic M3 receptors mediate contraction of human central and peripheral airway smooth muscle,” Pulmonary Pharmacology, vol. 3, no. 1, pp. 47–51, 1990.
- A. D. Fryer and J. Maclagan, “Muscarinic inhibitory receptors in pulmonary parasympathetic nerves in the guinea-pig,” British Journal of Pharmacology, vol. 83, no. 4, pp. 973–978, 1984.
- F. R. Coulson and A. D. Fryer, “Muscarinic acetylcholine receptors and airway diseases,” Pharmacology and Therapeutics, vol. 98, no. 1, pp. 59–69, 2003.
- L. P. Boulet, “Physiopathology of airway hyperresponsiveness,” Current Allergy and Asthma Reports, vol. 3, no. 2, pp. 166–171, 2003.
- E. Crimi, A. Spanevello, M. Neri, P. W. Ind, G. A. Rossi, and V. Brusasco, “Dissociation between airway inflammation and airway hyperresponsiveness in allergic asthma,” American Journal of Respiratory and Critical Care Medicine, vol. 157, no. 1, pp. 4–9, 1998.
- V. Brusasco, E. Crimi, P. Gianiorio, S. Lantero, and G. A. Rossi, “Allergen-induced increase in airway responsiveness and inflammation in mild asthma,” Journal of Applied Physiology, vol. 69, no. 6, pp. 2209–2214, 1990.
- J. Bousquet, D. P. Chanez, J. Y. Lacoste, et al., “Eosinophilic inflammation in asthma,” New England Journal of Medicine, vol. 323, no. 15, pp. 1033–1039, 1990.
- J. Corren, “Anti-interleukin-5 antibody therapy in asthma and allerges,” Current Opinion in Allergy and Clinical Immunology, vol. 11, no. 6, pp. 565–570, 2011.
- D. B. Jacoby, G. J. Gleich, and A. D. Fryer, “Human eosinophil major basic protein is an endogenous allosteric antagonist at the inhibitory muscarinic M2 receptor,” Journal of Clinical Investigation, vol. 91, no. 4, pp. 1314–1318, 1993.
- J. Hu, S. Z. Wang, C. Forray, and E. E. El-Fakahany, “Complex allosteric modulation of cardiac muscarinic receptors by protamine: potential model for putative endogenous ligands,” Molecular Pharmacology, vol. 42, no. 2, pp. 311–321, 1992.
- A. D. Fryer and D. B. Jacoby, “Function of pulmonary M2 muscarinic receptors in antigen-challenged guinea pigs is restored by heparin and poly-L-glutamate,” Journal of Clinical Investigation, vol. 90, no. 6, pp. 2292–2298, 1992.
- A. Fryer, Y. C. Huang, G. Rao et al., “Selective O-desulfation produces nonanticoagulant heparin that retains pharmacological activity in the lung,” Journal of Pharmacology and Experimental Therapeutics, vol. 282, no. 1, pp. 208–219, 1997.
- C. L. Elbon, D. B. Jacoby, and A. D. Fryer, “Pretreatment with an antibody to interleukin-5 prevents loss of pulmonary M2 muscarinic receptor function in antigen-challenged guinea pigs,” American Journal of Respiratory Cell and Molecular Biology, vol. 12, no. 3, pp. 320–328, 1995.
- K. E. Belmonte, “Cholinergic pathways in the lungs and anticholinergic therapy for chronic obstructive pulmonary disease,” Proceedings of the American Thoracic Society, vol. 2, no. 4, pp. 297–304, 2005.
- M. Rosas-Ballina and K. J. Tracey, “Cholinergic control of inflammation,” Journal of Internal Medicine, vol. 265, no. 6, pp. 663–679, 2009.
- K. J. Tracey, “The inflammatory reflex,” Nature, vol. 420, no. 6917, pp. 853–859, 2002.
- J. E. Blalock, “Harnessing a neural-immune circuit to control inflammation and shock,” Journal of Experimental Medicine, vol. 195, no. 6, pp. F25–F28, 2002.
- M. R. Blanchet, E. Israël-Assayag, and Y. Cormier, “Modulation of airway inflammation and resistance in mice by a nicotinic receptor agonist,” European Respiratory Journal, vol. 26, no. 1, pp. 21–27, 2005.
- O. M. Ibanez, C. Stiffel, O. G. Ribeiro et al., “Genetics of nonspecific immunity: I. Bidirectional selective breeding of lines of mice endowed with maximal or minimal inflammatory responsiveness,” European Journal of Immunology, vol. 22, no. 10, pp. 2555–2563, 1992.
- L. C. Peters, J. R. Jensen, A. Borrego et al., “Slc11a1 (formerly NRAMP1) gene modulates both acute inflammatory reactions and pristane-induced arthritis in mice,” Genes and Immunity, vol. 8, no. 1, pp. 51–56, 2007.
- D. A. Maria, G. Manenti, F. Galbiati et al., “Pulmonary adenoma susceptibility 1 (Pas1) locus affects inflammatory response,” Oncogene, vol. 22, no. 3, pp. 426–432, 2003.
- A. Borrego, L. C. Peters, J. R. Jensen et al., “Genetic determinants of acute inflammation regulate Salmonella infection and modulate Slc11a1 gene (formerly Nramp1) effects in selected mouse lines,” Microbes and Infection, vol. 8, no. 12-13, pp. 2766–2771, 2006.
- R. C. Levitt and W. Mitzner, “Expression of airway hyperreactivity to acetylcholine as a simple autosomal recessive trait in mice,” The FASEB Journal, vol. 2, no. 10, pp. 2605–2608, 1988.
- R. C. Levitt and W. Mitzner, “Autosomal recessive inheritance of airway hyperreactivity to 5-hydroxytyptamine,” Journal of Applied Physiology, vol. 67, no. 3, pp. 1125–1132, 1989.
- G. T. De Sanctis, M. Merchant, D. R. Beier et al., “Quantitative locus analysis of airway hyperresponsiveness in A/J and C57BL/6J mice,” Nature Genetics, vol. 11, no. 2, pp. 150–154, 1995.
- G. T. De Sanctis, M. Daheshia, and A. Daser, “Molecular mechanisms in allergy and clinical immunology: genetics of airway hyperresponsiveness,” Journal of Allergy and Clinical Immunology, vol. 108, no. 1, pp. 11–20, 2001.
- M. A. Carey, J. W. Card, J. A. Bradbury, et al., “Spontaneous airway hyperresponsiveness in estrogen receptor-alpha-deficient mice,” American Journal of Respiratory and Critical Care Medicine, vol. 175, no. 2, pp. 126–135, 2007.
- G. L. Larsen, T. M. Fame, H. Renz et al., “Increased acetylcholine release in tracheas from allergen-exposed IgE-immune mice,” American Journal of Physiology, vol. 266, no. 3, pp. L263–L270, 1994.
- A. D. Fryer and M. Wills-Karp, “Dysfunction of M2-muscarinic receptors in pulmonary parasympathetic nerves after antigen challenge,” Journal of Applied Physiology, vol. 71, no. 6, pp. 2255–2261, 1991.
- S. L. Ewart, D. Kuperman, E. Schadt et al., “Quantitative trait loci controlling allergen-induced airway hyperresponsiveness in inbred mice,” American Journal of Respiratory Cell and Molecular Biology, vol. 23, no. 4, pp. 537–545, 2000.
- H. Hadeiba, D. B. Corry, and R. M. Locksley, “Baseline airway hyperreactivity in A/J mice is not mediated by cells of the adaptive immune system,” Journal of Immunology, vol. 164, no. 9, pp. 4933–4940, 2000.
- R. M. Eglen, S. S. Hegde, and N. Watson, “Muscarinic receptor subtypes and smooth muscle function,” Pharmacological Reviews, vol. 48, no. 4, pp. 531–565, 1996.
- A. D. Fryer, D. J. Adamko, B. L. Yost, and D. B. Jacoby, “Effects of inflammatory cells on neuronal M2 muscarinic receptor function in the lung,” Life Sciences, vol. 64, no. 6-7, pp. 449–455, 1999.
- P. W. Stengel, J. Gomeza, J. Wess, and M. L. Cohen, “M2 and M4 receptor knockout mice: muscarinic receptor function in cardiac and smooth muscle in vitro,” Journal of Pharmacology and Experimental Therapeutics, vol. 292, no. 3, pp. 877–885, 2000.
- J. Garssen, H. Van Loveren, C. M. Gierveld, H. Van der Vliet, and F. P. Nijkamp, “Functional characterization of muscarinic receptors in murine airways,” British Journal of Pharmacology, vol. 109, no. 1, pp. 53–60, 1993.
- J. T. Fisher, S. G. Vincent, J. Gomeza, M. Yamada, and J. Wess, “Loss of vagally mediated bradycardia and bronchoconstriction in mice lacking M2 or M3 muscarinic acetylcholine receptors,” The FASEB Journal, vol. 18, no. 6, pp. 711–713, 2004.
- A. Ricci, F. Amenta, E. Bronzetti, F. Mannino, S. Mariotta, and S. Khosrow Tayebati, “Expression of peripheral blood lymphocyte muscarinic cholinergic receptor subtypes in airway hyperresponsiveness,” Journal of Neuroimmunology, vol. 129, no. 1-2, pp. 178–185, 2002.
- A. Ricci, S. Mariotta, F. Amenta, S. K. Tayebati, and C. Terzano, “Changes in muscarinic cholinergic receptor expression in human peripheral blood lymphocytes in allergic rhinitis patients,” Pulmonary Pharmacology and Therapeutics, vol. 21, no. 1, pp. 79–87, 2008.
- C. Perkins, N. Yanase, G. Smulian et al., “Selective stimulation of IL-4 receptor on smooth muscle induces airway hyperresponsiveness in mice,” Journal of Experimental Medicine, vol. 208, no. 4, pp. 853–867, 2011.
- O. Tliba, D. Deshpande, H. Chen et al., “IL-13 enhances agonist-evoked calcium signals and contractile responses in airway smooth muscle,” British Journal of Pharmacology, vol. 140, no. 7, pp. 1159–1162, 2003.
- O. G. Ribeiro, D. A. Maria, S. Adriouch et al., “Convergent alteration of granulopoiesis, chemotactic activity, and neutrophil apoptosis during mouse selection for high acute inflammatory response,” Journal of Leukocyte Biology, vol. 74, no. 4, pp. 497–506, 2003.
- L. V. Borovikova, S. Ivanova, M. Zhang et al., “Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin,” Nature, vol. 405, no. 6785, pp. 458–462, 2000.
- K. J. Tracey, “Reflex control of immunity,” Nature Reviews Immunology, vol. 9, no. 6, pp. 418–428, 2009.
- F. Vorraro, A. Galvan, W. H. K. Cabrera et al., “Genetic control of IL-1β production and inflammatory response by the mouse Irm1 locus,” Journal of Immunology, vol. 185, no. 3, pp. 1616–1621, 2010.
- R. Gosens, J. Zaagsma, H. Meurs, and A. J. Halayko, “Muscarinic receptor signaling in the pathophysiology of asthma and COPD,” Respiratory Research, vol. 7, p. 73, 2006.
- S. E. Wenzel, “Asthma phenotypes: the evolution from clinical to molecular approaches,” Nature Medicine, vol. 18, no. 5, pp. 716–725, 2012.
- A. Galvan, F. Vorraro, W. Cabrera et al., “Association study by genetic clustering detects multiple inflammatory response loci in non-inbred mice,” Genes and Immunity, vol. 12, no. 5, pp. 390–394, 2011.
- J. Bortolatto, E. Borducchi, D. Rodriguez et al., “Toll-like receptor 4 agonists adsorbed to aluminium hydroxide adjuvant attenuate ovalbumin-specific allergic airway disease: role of MyD88 adaptor molecule and interleukin-12/interferon-gamma axis,” Clinical and Experimental Allergy, vol. 38, no. 10, pp. 1668–1679, 2008.
- D. Rodríguez, A. C. Keller, E. L. Faquim-Mauro et al., “Bacterial lipopolysaccharide signaling through Toll-like receptor 4 suppresses asthma-like responses via nitric oxide synthase 2 activity,” Journal of Immunology, vol. 171, no. 2, pp. 1001–1008, 2003.
- A. C. Keller, D. Mucida, E. Gomes et al., “Hierarchical suppression of asthma-like responses by mucosal tolerance,” Journal of Allergy and Clinical Immunology, vol. 117, no. 2, pp. 283–290, 2006.
- J. M. Van Rossum, “Cumulative dose-response curves. II. Technique for the making of dose-response curves in isolated organs and the evaluation of drug parameters,” Archives internationales de pharmacodynamie et de thérapie, vol. 143, pp. 299–330, 1963.
- M. Russo, M. A. Nahori, J. Lefort, et al., “Suppression of asthma-like responses in different mouse strains by oral tolerance,” American Journal of Respiratory Cell and Molecular Biology, vol. 24, no. 5, pp. 518–526, 2001.
- R. R. Resende, L. R. G. Britto, and H. Ulrich, “Pharmacological properties of purinergic receptors and their effects on proliferation and induction of neuronal differentiation of P19 embryonal carcinoma cells,” International Journal of Developmental Neuroscience, vol. 26, no. 7, pp. 763–777, 2008.
- R. R. Resende, A. S. Alves, L. R. G. Britto, and H. Ulrich, “Role of acetylcholine receptors in proliferation and differentiation of P19 embryonal carcinoma cells,” Experimental Cell Research, vol. 314, no. 7, pp. 1429–1443, 2008.
- R. R. Resende, K. N. Gomes, A. Adhikari, L. R. G. Britto, and H. Ulrich, “Mechanism of acetylcholine-induced calcium signaling during neuronal differentiation of P19 embryonal carcinoma cells in vitro,” Cell Calcium, vol. 43, no. 2, pp. 107–121, 2008.
- R. R. Resende, A. Adhikari, J. L. da Costa et al., “Influence of spontaneous calcium events on cell-cycle progression in embryonal carcinoma and adult stem cells,” Biochimica et Biophysica Acta, vol. 1803, no. 2, pp. 246–260, 2010.