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BioMed Research International
Volume 2013 (2013), Article ID 808713, 9 pages
Effects of Anesthesia and Species on the Uptake or Binding of Radioligands In Vivo in the Göttingen Minipig
1Department of Nuclear Medicine and PET Center, Aarhus University Hospital, Nørrebrogade 44, Building 10G, 6th Floor, 8000 Aarhus, Denmark
2Center of Functionally Integrative Neuroscience/MINDLab, Aarhus University, Nørrebrogade 44, Building 10G, 5th Floor, 8000 Aarhus, Denmark
3Department of Medical Physics, University of Wisconsin, B1137 Wisconsin Institutes for Medical Research, UW-Medical Physics, Madison, WI 53706, USA
4Translational Neuropsychiatry Unit, Aarhus University, Skovagervej 2, 8240 Risskov, Denmark and Pharmaceutical Research Center of Excellence, North-West University, Potchefstroom, South Africa
5Department of Veterinary Disease Biology, Faculty of Life Sciences, University of Copenhagen, Thorvaldsensvej 57, 1871 Frederiksberg C, Denmark
6Department of Neuroscience and Pharmacology, University of Copenhagen, Blegdamsvej 3B, 2200 Copenhagen N, Denmark
7Department of Neurology, University of British Columbia, Purdy Pavillion, University of British Columbia, 2221 Wesbrook Mall, Vancouver, BC, Canada V6T 2B5
Received 30 April 2013; Revised 15 July 2013; Accepted 15 July 2013
Academic Editor: John J. Gildea
Copyright © 2013 Aage K. O. Alstrup et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- C. F. Ferris, M. Febo, F. Luo et al., “Functional magnetic resonance imaging in conscious animals: a new tool in behavioural neuroscience research,” Journal of Neuroendocrinology, vol. 18, no. 5, pp. 307–318, 2006.
- H. Tsukada, K. Miyasato, T. Kakiuchi, S. Nishiyama, N. Harada, and E. F. Domino, “Comparative effects of methamphetamine and nicotine on the striatal [11C]raclopride binding in unanesthetized monkeys,” Synapse, vol. 45, no. 4, pp. 207–212, 2002.
- G. Rauchs, X. Blaizot, C. Giffard, J. C. Baron, R. Insausti, and C. Chavoix, “Imaging visual recognition memory network by PET in the baboon: perirhinal cortex heterogeneity and plasticity after perirhinal lesion,” Journal of Cerebral Blood Flow and Metabolism, vol. 26, no. 3, pp. 301–309, 2006.
- W. Hassoun, M. Le Cavorsin, N. Ginovart et al., “PET study of the [11C]raclopride binding in the striatum of the awake cat: effects of anaesthetics and role of cerebral blood flow,” European Journal of Nuclear Medicine and Molecular Imaging, vol. 30, no. 1, pp. 141–148, 2003.
- H. Tsukada, S. Nishiyama, T. Kakiuchi et al., “Isoflurane anesthesia enhances the inhibitory effects of cocaine and GBR12909 on dopamine transporter: PET studies in combination with microdialysis in the monkey brain,” Brain Research, vol. 849, no. 1-2, pp. 85–96, 1999.
- N. M. Lind, A. Moustgaard, J. Jelsing, G. Vajta, P. Cumming, and A. K. Hansen, “The use of pigs in neuroscience: modeling brain disorders,” Neuroscience and Biobehavioral Reviews, vol. 31, no. 5, pp. 728–751, 2007.
- V. D. Patel, D. E. Lee, D. L. Alexoff, S. L. Dewey, and W. K. Schiffer, “Imaging dopamine release with Positron Emission Tomography (PET) and 11C-raclopride in freely moving animals,” NeuroImage, vol. 41, no. 3, pp. 1051–1066, 2008.
- D. J. Doudet, S. Jivan, T. J. Ruth, and R. J. Wyatt, “In vivo PET studies of the dopamine D1 receptors in rhesus monkeys with long-term MPTP-induced parkinsonism,” Synapse, vol. 44, no. 2, pp. 111–115, 2002.
- A. K. O. Alstrup, Anesthesia and Analgesia of the Ellegaard Gottingen Minipig, Jannerup, Dalmose, Denmark, 1st edition, 2010.
- H. Watanabe, F. Andersen, C. Z. Simonsen, S. M. Evans, A. Gjedde, and P. Cumming, “MR-based statistical atlas of the Göttingen minipig brain,” NeuroImage, vol. 14, no. 5, pp. 1089–1096, 2001.
- L. Minuzzi, A. K. Olsen, D. Bender et al., “Quantitative autoradiography of ligands for dopamine receptors and transporters in brain of Göttingen Minipig: comparison with results in vivo,” Synapse, vol. 59, no. 4, pp. 211–219, 2006.
- S. Jakobsen, K. Pedersen, D. F. Smith, S. B. Jensen, O. L. Munk, and P. Cumming, “Detection of α2-adrenergic receptors in brain of living pig with11C-yohimbine,” Journal of Nuclear Medicine, vol. 47, no. 12, pp. 2008–2015, 2006.
- J. Logan, J. S. Fowler, N. D. Volkow et al., “Graphical analysis of reversible radioligand binding from time-activity measurements applied to [N-11C-methyl]-(-)-cocaine PET studies in human subjects,” Journal of Cerebral Blood Flow and Metabolism, vol. 10, no. 5, pp. 740–747, 1990.
- J. Logan, J. S. Fowler, N. D. Volkow, G. J. Wang, Y. S. Ding, and D. L. Alexoff, “Distribution volume ratios without blood sampling from graphical analysis of PET data,” Journal of Cerebral Blood Flow and Metabolism, vol. 16, no. 5, pp. 834–840, 1996.
- J. L. Graner, V. Sossi, and J. E. Holden, “A universal graphical analysis for the simultaneous evaluation of both uptake rate constants and equilibrium distribution volumes,” NeuroImage, vol. 41, supplement 2, p. T24, 2008.
- D. J. Doudet, G. L. Chan, J. E. Holden et al., “6-[18F]Fluoro-L-DOPA PET studies of the turnover of dopamine in MPTP-induced parkinsonism in monkeys,” Synapse, vol. 29, no. 3, pp. 225–232, 1998.
- V. Sossi, D. J. Doudet, and J. E. Holden, “A reversible tracer analysis approach to the study of effective dopamine turnover,” Journal of Cerebral Blood Flow and Metabolism, vol. 21, no. 4, pp. 469–476, 2001.
- A. Gjedde, “Calculation of cerebral glucose phosphorylation from brain uptake of glucose analogs in vivo: a re-examination,” Brain Research, vol. 257, no. 2, pp. 237–274, 1982.
- C. S. Patlak and R. G. Blasberg, “Graphical evaluation of blood-to-brain transfer constants from multiple-time uptake data. Generalizations,” Journal of Cerebral Blood Flow and Metabolism, vol. 5, no. 4, pp. 584–590, 1985.
- G. L. Y. Chan, J. E. Holden, A. J. Stoessl et al., “Reproducibility of the distribution of carbon-11-SCH 23390, a dopamine D1 receptor tracer, in normal subjects,” Journal of Nuclear Medicine, vol. 39, no. 5, pp. 792–797, 1998.
- A. A. Lammertsma and S. P. Hume, “Simplified reference tissue model for PET receptor studies,” NeuroImage, vol. 4, no. 3, pp. 153–158, 1996.
- G. De Cosmo, I. Cancelli, A. Adduci, G. Merlino, P. Aceto, and M. Valente, “Changes in hemodynamics during isoflurane and propofol anesthesia: a comparison study,” Neurological Research, vol. 27, no. 4, pp. 433–435, 2005.
- P. Le Corre, R. J. Parmer, M. T. Kailasam et al., “Human sympathetic activation by α2-adrenergic blockade with yohimbine: bimodal, epistatic influence of cytochrome P450-mediated drug metabolism,” Clinical Pharmacology and Therapeutics, vol. 76, no. 2, pp. 139–153, 2004.
- M. D. Walker, K. Dinelle, R. Kornelsen et al., “In-vivo measurement of LDOPA uptake, dopamine reserve and turnover in the rat brain using [(18)F]FDOPA PET,” Journal of Cerebral Blood Flow & Metabolism, vol. 33, no. 1, pp. 59–66, 2013.
- P. Cumming, B. E. Boyes, and W. R. Wayne Martin, “Altered metabolism of [18F]-6-fluorodopa in the hooded rat following inhibition of catechol-O-methyltransferase with U-0521,” Biochemical Pharmacology, vol. 36, no. 15, pp. 2527–2531, 1987.
- R. Hargreaves, “Imaging substance P receptors (NK1) in the living human brain using positron emission tomography,” Journal of Clinical Psychiatry, vol. 63, supplement 11, pp. 18–24, 2002.
- P. Rosa-Neto, A. Gjedde, A. K. Olsen et al., “MDMA-evoked changes in [11C]raclopride and [11C]NMSP binding in living pig brain,” Synapse, vol. 53, no. 4, pp. 222–233, 2004.
- M. Bergstrom, A. Grahnen, and B. Langstrom, “Positron emission tomography microdosing: a new concept with application in tracer and early clinical drug development,” European Journal of Clinical Pharmacology, vol. 59, no. 5-6, pp. 357–366, 2003.
- C. C. Wagner and O. Langer, “Approaches using molecular imaging technology—use of PET in clinical microdose studies,” Advanced Drug Delivery Reviews, vol. 63, no. 7, pp. 539–546, 2011.
- S. Momosaki, K. Hatano, Y. Kawasumi et al., “Rat-PET study without anesthesia: anesthetics modify the dopamine D 1 receptor binding in rat brain,” Synapse, vol. 54, no. 4, pp. 207–213, 2004.
- P. Fiset, T. Paus, T. Daloze et al., “Brain mechanisms of propofol-induced loss of consciousness in humans: a positron emission tomographic study,” Journal of Neuroscience, vol. 19, no. 13, pp. 5506–5513, 1999.
- K. K. Kaisti, J. W. Långsjö, S. Aalto et al., “Effects of sevoflurane, propofol, and adjunct nitrous oxide on regional cerebral blood flow, oxygen consumption and blood volume in humans,” Anesthesiology, vol. 99, no. 3, pp. 603–613, 2003.
- M. Enlund, J. Andersson, P. Hartvig, J. Valtysson, and L. Wiklund, “Cerebral normoxia in the rhesus monkey during isoflurane- or propofol- induced hypotension and hypocapnia, despite disparate blood-flow patterns. A positron emission tomography study,” Acta Anaesthesiologica Scandinavica, vol. 41, no. 8, pp. 1002–1010, 1997.
- Y. Kuroda, M. Murakami, J. Tsuruta, T. Murakawa, and T. Sakabe, “Preservation of the ratio of cerebral blood flow/metabolic rate for oxygen during prolonged anesthesia with isoflurane, sevoflurane, and halothane in humans,” Anesthesiology, vol. 84, no. 3, pp. 555–561, 1996.
- M. Lagerkranser, K. Stånge, and A. Sollevi, “Effects of propofol on cerebral blood flow, metabolism, and cerebral autoregulation in the anesthetized pig,” Journal of Neurosurgical Anesthesiology, vol. 9, no. 2, pp. 188–193, 1997.
- D. W. Schultz, L. Staples, and R. B. Mailman, “SCH23390 causes persistent antidopaminergic effects in vivo: evidence for longterm occupation of receptors,” Life Sciences, vol. 36, no. 20, pp. 1941–1948, 1985.
- A. N. Gifford, S. J. Gatley, and N. D. Volkow, “Evaluation of the importance of rebinding to receptors in slowing the approach to equilibrium of high-affinity PET and SPECT radiotracers,” Synapse, vol. 28, no. 2, pp. 167–175, 1998.
- X. Sun, H. Zhang, C. Gao et al., “Imaging the effects of propofol on human cerebral glucose metabolism using positron emission tomography,” Journal of International Medical Research, vol. 36, no. 6, pp. 1305–1310, 2008.
- H. Toyama, M. Ichise, J. S. Liow et al., “Evaluation of anesthesia effects on [18F]FDG uptake in mouse brain and heart using small animal PET,” Nuclear Medicine and Biology, vol. 31, no. 2, pp. 251–256, 2004.
- C. C. Constantinescu, R. A. Coleman, M. L. Pan, and J. Mukherjee, “Striatal and extrastriatal microPET imaging of D2/D3 dopamine receptors in rat brain with [18F]fallypride and [18F]desmethoxyfallypride,” Synapse, vol. 65, no. 8, pp. 778–787, 2011.