Curcumin Inhibits Tumor Growth and Angiogenesis in an Orthotopic Mouse Model of Human Pancreatic Cancer
Figure 1
Curcumin inhibits proliferation and enhances apoptosis in MIA PaCa-2 cells. (a)–(f) Wound assay results show suppression of MIA PaCa-2 cell proliferation induced by curcumin at 48 h (b) With respect to controls. The results are the mean of total invaded areas of three distinct sections on the slide per 48 h. (, Mann-Whitney U test). (g) MTT assay results show a suppression of proliferation in pancreatic cancer cells treated with curcumin respect to control cells. Data are representative of two independent experiments ( value <0.05). (h) In vitro apoptosis assay by flow cytometry indicated that curcumin enhances apoptosis in MIA PaCa-2 cells. (i) EMSA results showes that curcumin suppresses activation of NF-κB in MIA PACA-2 cells. (j) In vitro apoptosis assay by flow cytometry indicates that silencing of NF-κB using siRNA κB is not able to potentiate the apoptotic effects of curcumin on MIA PaCa-2 cells.
