HBV Induced HCC: Major Risk Factors from Genetic to Molecular Level

Table 2

Genes down regulated during HBV induced hepatocellular carcinoma

Genes Down regulated during HCC:
Gene	Gene name	Activated by	Function	Reference
BID	BH3 interacting domain	HBx protein	Cell death regulation	[106]
P53	Protein 53	HBx	Tumor suppressor	[107]
p21WAF1	Protein 21	HBx	Stress response, acts with p53	[107]
IGFBP3	Insulin-like growth factor-binding protein 3	HBx		[107]
CASP8	Caspase 8	HBV	Apoptosis-related cysteine peptidase	[89]
CDKN1A/p21	Cyclin-dependent kinase inhibitor 1A	HBV	Inhibits the activity of cyclin-CDK2	[107]
DLC1	Deleted in liver cancer 1	HBV	Tumor suppressor, cell growth, and proliferation	[108]
FADD	Fas-associated protein with death domain	HBV	Adaptor molecule that bridges the Fas-receptor	[109]
IGFBP1	Insulin-like growth factor-binding protein 1	HBV	Tumor suppressor	[110]
ITGB1	Integrins beta 1	HBV	Embryogenesis, hemostasis, tissue repair, immune response	[111]
Hhip	Hh-interacting protein	HBV	Modulates hedgehog signaling	[112]
PTEN		HBV	Apoptosis, cell movement	[113]
RB1	Retinoblastoma 1	HBV	Oncogenic, tumor suppressor	[114]
SMAD4		HBV	Transmitting chemical signal, regulates cell growth and division	[115]
SOCS1	Suppressor of cytokine signaling 1	HBV	Negative regulator in TNF-induced inflammation and activation of c-jun N-terminal kinase	[116]
SOCS3	Suppressor of cytokine signaling 3	HBV		[117]
TGFBR2	Transforming growth factor, beta receptor II	HBV	Transmits signals, stimulation of cell growth and division, differentiation	[118]
CDKN2A	Cyclin-dependent kinase inhibitor 2A	HBV and HCV	Cell cycle control, tumor suppressor gene	[119]